Ian Read Gibbons, (30 October 1931 – 30 January 2018) was a

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

and cell biologist. He discovered and named

dynein Dyneins are a family of cytoskeletal motor proteins (though they are actually protein complexes) that move along microtubules in cells. They convert the chemical energy stored in ATP to mechanical work. Dynein transports various cellular cargo ...

, and demonstrated energy source as ATP is sufficient for dynein to walk on

microtubules Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 an ...

. In 2017, he and Ronald Vale received the Shaw Prize for their research on microtubule motor proteins. He was elected a Fellow of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

of Great Britain in 1983. The Society stated: :He discovered, named and characterised the founding member of the dynein ATPase family of motor proteins and other microtubular components in cilia and flagella. By elegantly combining biochemical techniques with light and electron microscopy, he greatly advanced our understanding of microtubule-based motility, particularly by the direct visual demonstration of active dynein-dependent sliding between adjacent microtubules in structurally weakened flagella.

Early life and education

Gibbons's passion for science stemmed from his interest in radio. He entered Queen Elizabeth's Grammar School in

Faversham Faversham () is a market town in Kent, England, from Sittingbourne, from London and from Canterbury, next to the Swale, a strip of sea separating mainland Kent from the Isle of Sheppey in the Thames Estuary. It is close to the A2 road (Great ...

in 1943, where he developed an interest towards

applied physics Applied physics is the application of physics to solve scientific or engineering problems. It is usually considered a bridge or a connection between physics and engineering. "Applied" is distinguished from "pure" by a subtle combination of fac ...

. Following 18 months in the

Royal Air Force The Royal Air Force (RAF) is the Air force, air and space force of the United Kingdom, British Overseas Territories and Crown Dependencies. It was formed towards the end of the World War I, First World War on 1 April 1918, on the merger of t ...

as a

radar Radar is a system that uses radio waves to determine the distance ('' ranging''), direction ( azimuth and elevation angles), and radial velocity of objects relative to the site. It is a radiodetermination method used to detect and track ...

engineer, he was admitted into

King's College, Cambridge King's College, formally The King's College of Our Lady and Saint Nicholas in Cambridge, is a List of colleges of the University of Cambridge, constituent college of the University of Cambridge. The college lies beside the River Cam and faces ...

, in 1951 to read

physics Physics is the scientific study of matter, its Elementary particle, fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge whi ...

. He graduated with a

bachelor's degree A bachelor's degree (from Medieval Latin ''baccalaureus'') or baccalaureate (from Modern Latin ''baccalaureatus'') is an undergraduate degree awarded by colleges and universities upon completion of a course of study lasting three to six years ...

and then, in 1957, a

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

degree from Cambridge. His PhD research concerns using

electron microscopes An electron microscope is a microscope that uses a beam of electrons as a source of illumination. It uses electron optics that are analogous to the glass lenses of an optical light microscope to control the electron beam, for instance focusing i ...

to study the organisation of

chromosomes A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most importa ...

during

mitosis Mitosis () is a part of the cell cycle in eukaryote, eukaryotic cells in which replicated chromosomes are separated into two new Cell nucleus, nuclei. Cell division by mitosis is an equational division which gives rise to genetically identic ...

and

meiosis Meiosis () is a special type of cell division of germ cells in sexually-reproducing organisms that produces the gametes, the sperm or egg cells. It involves two rounds of division that ultimately result in four cells, each with only one c ...

. Gibbons then went to the

University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...

as a

postdoctoral researcher A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary acade ...

, where he stayed for 1 year. He subsequently moved to the Department of

Biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

, to take up the post of director of the newly founded electron microscopy laboratory.

Academic and research career

While at

Harvard Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher lear ...

, Gibbons studied the structure of

cilia The cilium (: cilia; ; in Medieval Latin and in anatomy, ''cilium'') is a short hair-like membrane protrusion from many types of eukaryotic cell. (Cilia are absent in bacteria and archaea.) The cilium has the shape of a slender threadlike proj ...

and

flagella A flagellum (; : flagella) (Latin for 'whip' or 'scourge') is a hair-like appendage that protrudes from certain plant and animal sperm cells, from fungal spores ( zoospores), and from a wide range of microorganisms to provide motility. Many pr ...

of a

protozoan Protozoa (: protozoan or protozoon; alternative plural: protozoans) are a polyphyletic group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic debris. Historically ...

called '' Tetrahymena'' with

. In 1963, he discovered a novel

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

and published its pictures. Two years later, he purified two regions of the protein, known as its two "arms", naming the protein "

". During his last year at Harvard, Gibbons demonstrated the protein making up microtubules was distinct from

actin Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ...

, in that the former was associated with

guanine Guanine () (symbol G or Gua) is one of the four main nucleotide bases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine ( uracil in RNA). In DNA, guanine is paired with cytosine. The guanine nucleoside ...

nucleotides Nucleotides are Organic compound, organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both o ...

while the latter with

adenine Adenine (, ) (nucleoside#List of nucleosides and corresponding nucleobases, symbol A or Ade) is a purine nucleotide base that is found in DNA, RNA, and Adenosine triphosphate, ATP. Usually a white crystalline subtance. The shape of adenine is ...

nucleotides, but refrained from naming it; Hideo Mohri from the

University of Tokyo The University of Tokyo (, abbreviated as in Japanese and UTokyo in English) is a public research university in Bunkyō, Tokyo, Japan. Founded in 1877 as the nation's first modern university by the merger of several pre-westernisation era ins ...

named it

tubulin Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytosk ...

afterwards. Gibbons moved to the Kewalo Marine Laboratory,

University of Hawaiʻi at Mānoa The University of Hawaii at Mānoa is a Public university, public Land-grant university, land-grant research university in Honolulu, Hawaii, United States. It is the flagship campus of the University of Hawaiʻi system and houses the main offic ...

, in 1967 as an

associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. In the ''North American system'', used in the United States and many other countries, it is a position ...

. He found the cilia of

sea urchin Sea urchins or urchins () are echinoderms in the class (biology), class Echinoidea. About 950 species live on the seabed, inhabiting all oceans and depth zones from the intertidal zone to deep seas of . They typically have a globular body cove ...

sperms easier to work with than the cilia and flagella of ''Tetrahymena''. In 1969, he was promoted to

professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin ...

biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

. Throughout the 1970s, Gibbons and his wife Barbara showed the sliding of microtubules caused cilia motility (known as the sliding tubule mechanism), and that this sliding was dependent on the energy generated from ATP hydrolysis by

ATPase ATPases (, Adenosine 5'-TriPhosphatase, adenylpyrophosphatase, ATP monophosphatase, triphosphatase, ATP hydrolase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion or ...

. When microtubules visibly slid out of the ends of the flagellar fiber, the flagella disintegrated. He then extended the mechanism to

mammals A mammal () is a vertebrate animal of the class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three middle e ...

, confirming the motility mechanism of

bull A bull is an intact (i.e., not Castration, castrated) adult male of the species ''Bos taurus'' (cattle). More muscular and aggressive than the females of the same species (i.e. cows proper), bulls have long been an important symbol cattle in r ...

sperm cilia is the same as that for sea urchins. After these findings, Gibbons switched his focus to the

molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

of dyneins, and determined the

DNA sequence A nucleic acid sequence is a succession of bases within the nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule. This succession is denoted by a series of a set of five different letters that indicate the order of the nu ...

of the largest subunit of dynein in 1991. In 1993, he became the director of the Kewalo Marine Laboratory. Ian and Barbara Gibbons retired from the University of Hawaiʻi at Mānoa in 1997; he went to the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...

as a research scientist in the laboratory of Beth Burnside. In 2009, Burnside closed her laboratory, and Gibbons became a

visiting researcher In academia, a visiting scholar, visiting scientist, visiting researcher, visiting fellow, visiting lecturer, or visiting professor is a scholar from an institution who visits a host university to teach, lecture, or perform research on a topic fo ...

Honours and awards

* Shaw Prize in Life Science and Medicine (2017) *

International Prize for Biology The is an annual award for "outstanding contribution to the advancement of research in fundamental biology." The Prize, although it is not always awarded to a biologist, is one of the most prestigious honours a natural scientist can receive. Ther ...

Japan Society for the Promotion of Science The is an Independent Administrative Institution in Japan, established for the purpose of contributing to the advancement of science in all fields of the natural and social sciences and the humanities.JSPSweb page History The Japan Society f ...

(1995) * E.B. Wilson Medal, American Society for Cell Biology (1994) *

Fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

of the

(1983) *

Guggenheim Fellowship Guggenheim Fellowships are Grant (money), grants that have been awarded annually since by the John Simon Guggenheim Memorial Foundation, endowed by the late Simon Guggenheim, Simon and Olga Hirsh Guggenheim. These awards are bestowed upon indiv ...

Molecular A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemistry, ...

and

Cellular Biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the Anatomy, structure, Physiology, function, and behavior of cell (biology), cells. All living organisms are made of cells. A cell is the basic unit of life th ...

John Simon Guggenheim Memorial Foundation The John Simon Guggenheim Memorial Foundation is a private foundation formed in 1925 by Olga and Simon Guggenheim in memory of their son, who died on April 26, 1922. The organization awards Guggenheim Fellowship Guggenheim Fellowships are Gr ...

(1973)

Personal life

Gibbons met his wife Barbara while in

; they married in 1961. Barbara died in 2013 at age 81. Gibbons also died in 2018.

References

{{DEFAULTSORT:Gibbons, Ian R. 1931 births 2018 deaths British cell biologists British biophysicists British molecular biologists University of Hawaiʻi at Mānoa faculty Fellows of the Royal Society People from Rye, East Sussex