Fritz Heinrich Jakob Lewy, a German-American neurologist, first identified and described inclusions in the brain cells of patients with Parkinson’s disease and published his findings in the Lewandowsky’s Handbook of Neurology in 1912. I-cells also called inclusion cells are abnormal

fibroblast A fibroblast is a type of cell (biology), biological cell that synthesizes the extracellular matrix and collagen, produces the structural framework (Stroma (tissue), stroma) for animal Tissue (biology), tissues, and plays a critical role in wound ...

s having a large number of dark inclusions in the cytoplasm of the cell (mainly in the central area). They are metabolically inactive structures of a cell and are not enclosed by a membrane. The inclusions are of various fats, proteins, carbohydrates, pigments, excretory products, crystals, and other insolubles. They are found in the cytoplasm of a cell in both prokaryotes and eukaryotes. They are seen in

Mucolipidosis II Inclusion-cell (I-cell) disease, also referred to as mucolipidosis II (ML II), is part of the lysosomal storage disease family and results from a defective phosphotransferase (an enzyme of the Golgi apparatus). This enzyme transfers phosphate to m ...

, and

Mucolipidosis III Pseudo-Hurler polydystrophy, also referred to as mucolipidosis III (ML III), is a lysosomal storage disease closely related to I-cell disease (ML II). This disorder is called Pseudo-Hurler because it resembles a mild form of Hurler syndrome, one of ...

, also called inclusion-cell or I-cell disease where lysosomal enzyme transport and storage is affected. Inclusion bodies

Lewy bodies (alpha synuclein inclusions) 1

References

Cell biology {{cell-biology-stub