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Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Function

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.


Interactions

ITGB4 has been shown to interact with Collagen, type XVII, alpha 1, EIF6 and Erbin.


See also

*
Cluster of differentiation The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophe ...
* List of target antigens in pemphigoid


References


Further reading

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External links


GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia
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ITGB4
Info with links in th
Cell Migration Gateway
{{Integrins Clusters of differentiation Integrins