ISAM-140 is a selective non- xanthinic

adenosine Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside buildin ...

A_2B receptor atagonist. Discovered in 2016, has a K''_i'' of 3.49 nM in A_2B receptor and >1000-fold selectivity with respect to the other three adenosine receptor subtypes. It has been shown to help immune system to attack

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bl ...

cells in ''in vitro'' assays, by rescuing T and NK cell proliferation,

cytokine Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in a ...

release and TIL infiltration.

References

{{reflist 2-Furyl compounds Esters Nitrogen heterocycles Heterocyclic compounds with 3 rings