Hysterosalpingography (HSG), also known as uterosalpingography,
is a
radiologic procedure to investigate the shape of the uterine cavity and the shape and patency of the
fallopian tubes
The fallopian tubes, also known as uterine tubes, oviducts or salpinges (: salpinx), are paired tubular sex organs in the human female body that stretch from the ovaries to the uterus. The fallopian tubes are part of the female reproductive sy ...
. It is a special x-ray procedure using
dye
Juan de Guillebon, better known by his stage name DyE, is a French musician. He is known for the music video of the single "Fantasy
Fantasy is a genre of speculative fiction that involves supernatural or Magic (supernatural), magical ele ...
to look at the womb (
uterus
The uterus (from Latin ''uterus'', : uteri or uteruses) or womb () is the hollow organ, organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic development, embryonic and prenatal development, f ...
) and fallopian tubes.
In this procedure, a
radio-opaque material is injected into the
cervical canal, and radiographs are taken. A normal result shows the filling of the
uterine cavity
The uterine cavity is the inside of the uterus
The uterus (from Latin ''uterus'', : uteri or uteruses) or womb () is the hollow organ, organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic d ...
and the bilateral filling of the fallopian tube with the injection material. To demonstrate tubal patency, spillage of the material into the
peritoneal cavity
The peritoneal cavity is a potential space located between the two layers of the peritoneum—the parietal peritoneum, the serous membrane that lines the abdominal wall, and visceral peritoneum, which surrounds the internal organs. While situated ...
needs to be observed. Hysterosalpingography has vital role in treatment of infertility, especially in the case of fallopian tube blockage.
Uses
HSG is considered a
diagnostic procedure. It is used in the workup of
infertile
In biology, infertility is the inability of a male and female organism to reproduce. It is usually not the natural state of a healthy organism that has reached sexual maturity, so children who have not undergone puberty, which is the body's sta ...
females to assess the patency of
fallopian tubes
The fallopian tubes, also known as uterine tubes, oviducts or salpinges (: salpinx), are paired tubular sex organs in the human female body that stretch from the ovaries to the uterus. The fallopian tubes are part of the female reproductive sy ...
, assess the competency of the cervix or congenital abnormality of the uterus in multiple
miscarriages
Miscarriage, also known in medical terms as a spontaneous abortion, is an end to pregnancy resulting in the loss and expulsion of an embryo or fetus from the womb before it can survive independently. Miscarriage before 6 weeks of gestation i ...
, assess the patency of fallopian tubes after surgery or
tubal ligation
Tubal ligation (commonly known as having one's "tubes tied") is a surgical procedure for female sterilization in which the fallopian tubes are permanently blocked, clipped or removed. This prevents the fertilization of eggs by sperm and thus the ...
, or before reversal of tubal ligation. Rarely, HSG is used to assess the integrity of a
Caesarean scar.
Occasionally, HSG may also have
therapeutic
A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis. Both words, ''treatment'' and ''therapy'', are often abbreviated tx, Tx, or Tx.
As a rule, each therapy has indications an ...
benefits for
infertility treatment. When oil-based contrast is used, rates of pregnancy increase by about 10% compared to water-based contrast.
A meta-analysis revealed 3.6 times greater
odds
In probability theory, odds provide a measure of the probability of a particular outcome. Odds are commonly used in gambling and statistics. For example for an event that is 40% probable, one could say that the odds are or
When gambling, o ...
(OR = 3.6) of pregnancy with oil-based contrast compared to no hysterosalpingography.
This effect is thought to be due to the flushing action of the contrast into the uterus that causes dislodgement of mucus plug, debris, or opening of mild adhesions in the fallopian tubes.
HSG is contraindicated during menstruation, suspected cancer, pregnancy, unprotected sexual intercourse during the
menstrual cycle
The menstrual cycle is a series of natural changes in hormone production and the structures of the uterus and ovaries of the female reproductive system that makes pregnancy possible. The ovarian cycle controls the production and release of eg ...
, any purulent discharge from the vagina, or if the individual was diagnosed with
pelvic inflammatory disease
Pelvic inflammatory disease (PID), also known as pelvic inflammatory disorder, is an infection of the upper part of the female reproductive system, mainly the uterus, fallopian tubes, and ovaries, and inside of the pelvis. Often, there may be no ...
six months previously. For those with hypersensitivity to contrast, HSG is relatively contraindicated.
Procedure
Either high osmolar contrast material (HOCM) or low osmolar contrast material (LOCM) can be used. 10 to 20 ml of LOCM can be used at a concentration of 270 to 300 mg/ml. The contrast media should be prewarmed to room temperature before administered into the cervix, so as to prevent spasm of
fallopian tubes
The fallopian tubes, also known as uterine tubes, oviducts or salpinges (: salpinx), are paired tubular sex organs in the human female body that stretch from the ovaries to the uterus. The fallopian tubes are part of the female reproductive sy ...
. 5Fr to 7Fr hysterosalpingogram balloon catheter can be used. Margolin HSG cannula is used if the cervix is narrow or
stenosed.
HSG appointment is usually made during the 4th to 10th days of regular menstrual cycle (
follicular phase
The follicular phase, also known as the preovulatory phase or proliferative phase, is the phase of the estrous cycle (or, in primates for example, the menstrual cycle) during which follicles in the ovary mature from primary follicle to a full ...
).
The subject should not have undergone any sexual intercourse before HSG. Anxious subjects may need painkillers or other medications.
Informed consent
Informed consent is an applied ethics principle that a person must have sufficient information and understanding before making decisions about accepting risk. Pertinent information may include risks and benefits of treatments, alternative treatme ...
should be taken before the procedure.
The subject lies down on table in supine position with legs flexed and
abducted.
Vulva
In mammals, the vulva (: vulvas or vulvae) comprises mostly external, visible structures of the female sex organ, genitalia leading into the interior of the female reproductive tract. For humans, it includes the mons pubis, labia majora, lab ...
is cleaned with
chlorhexidine
Chlorhexidine is a disinfectant and antiseptic which is used for skin disinfection before surgery and to disinfect surgical instruments. It is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and ...
or
normal saline
Saline (also known as saline solution) is a mixture of sodium chloride (salt) and water. It has a number of uses in medicine including cleaning wounds, removal and storage of contact lenses, and help with dry eyes. By intravenous therapy, inje ...
. A speculum is inserted to the
vagina
In mammals and other animals, the vagina (: vaginas or vaginae) is the elastic, muscular sex organ, reproductive organ of the female genital tract. In humans, it extends from the vulval vestibule to the cervix (neck of the uterus). The #Vag ...
with the help of sterile jelly, and the
cervix
The cervix (: cervices) or cervix uteri is a dynamic fibromuscular sexual organ of the female reproductive system that connects the vagina with the uterine cavity. The human female cervix has been documented anatomically since at least the time ...
is exposed. The cervical opening is identified using a bright light. The HSG catheter is then inserted into the
cervical canal
The cervical canal is the spindle-shaped, flattened canal of the cervix which connects the vagina to the main cavity of the uterus in most mammals.
Anatomy
The cervical canal communicates with the uterine cavity via the internal orifice of the ...
. Occasionally, Vulsellum forceps may be used to hold the cervical lips open. If
cervical weakness is suspected, the catheter should be left inside the lower cervical canal.
Air bubbles should be expelled from the syringe and the catheter, otherwise it will cause confusion of interpretations on HSG. Contrast medium is injected slowly into the uterine cavity with intermittent
fluoroscopic
Fluoroscopy (), informally referred to as "fluoro", is an imaging technique that uses X-rays to obtain real-time moving images of the interior of an object. In its primary application of medical imaging, a fluoroscope () allows a surgeon to see t ...
screening. If there are no spills from bilateral fallopian tubes bilaterally, intravenous
buscopan and
glucagon
Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises the concentration of glucose and fatty acids in the bloodstream and is considered to be the main catabolic hormone of the body. It is also used as a Glucagon (medic ...
can be given to relieve spasm of fallopian tubes.
Opiate
An opiate is an alkaloid substance derived from opium (or poppy straw). It differs from the similar term ''opioid'' in that the latter is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain ( ...
s should not be given, as it may increase pain because of increased smooth muscle contractions.
The procedure involves x-rays (
fluoroscopy
Fluoroscopy (), informally referred to as "fluoro", is an imaging technique that uses X-rays to obtain real-time moving images of the interior of an object. In its primary application of medical imaging, a fluoroscope () allows a surgeon to see t ...
).
Images are taken to demonstrate the filling of
endometrial cavity, which shows full view of the fallopian tubes demonstrating the spillage of contrast material into
peritoneum
The peritoneum is the serous membrane forming the lining of the abdominal cavity or coelom in amniotes and some invertebrates, such as annelids. It covers most of the intra-abdominal (or coelomic) organs, and is composed of a layer of mesotheli ...
, the extent of the block if no spillage is present, or a delayed view in the case of abnormal cavities (
locule
A locule (: locules) or loculus (; : loculi) is a small cavity or compartment within an organ or part of an organism (animal, plant, or fungus).
In angiosperms (flowering plants), the term ''locule'' usually refers to a chamber within an ovary ...
) within. Subject may have vaginal spotting for one to two days, accompanied with pain that may persist for up to two weeks. Some medical centres routinely give
prophylactic
Preventive healthcare, or prophylaxis, is the application of healthcare measures to prevent diseases.Hugh R. Leavell and E. Gurney Clark as "the science and art of preventing disease, prolonging life, and promoting physical and mental health a ...
antibiotics before subject is allowed home.
Complications
Possible complications of the procedure include
infection
An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...
,
allergic
Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, alle ...
reactions to the materials used,
intravasation
Intravasation is the invasion of cancer cells through the basement membrane into a blood or lymphatic vessel. Intravasation is one of several carcinogenic events that initiate the escape of cancerous cells from their primary sites. Other mechanisms ...
of the contrast material, pain during the procedure, nausea, vomiting, and headache. Some subjects may develop
vasovagal syncope during the inflation of balloon in the cervical canal.
History
For the first HSG, Carey used
collargol in 1914.
Lipiodol
Iodized oil, also known as ethiodized oil, brand name Lipiodol, is a medication derived from poppyseed oil and iodine. When given by injection, it is a radio-opaque contrast agent that is used to outline structures in radiological investiga ...
was introduced by Sicard and Forestier in 1924, and remained a popular contrast medium for many decades.
Later, water-soluble contrast material was generally preferred as it avoided the possible complication of oil embolism.
Follow up
If the HSG indicates further investigations are warranted, a
laparoscopy
Laparoscopy () is an operation performed in the abdomen or pelvis using small incisions (usually 0.5–1.5 cm) with the aid of a camera. The laparoscope aids diagnosis or therapeutic interventions with a few small cuts in the abdomen.Medli ...
, assisted by
hysteroscopy
Hysteroscopy is the inspection of the uterine cavity by endoscopy with access through the cervix. It allows for the diagnosis of intrauterine pathology and serves as a method for surgical intervention (operative hysteroscopy).
Hysteroscope
A hyst ...
, may be advised to visualize the area in three dimensions, with the potential to resolve minor issues within the same procedure.
See also
*
Hydrosalpinx
*
Salpingitis isthmica nodosa
References
External links
HSG Test - HSG Test : Cost, Results, Expert Advice, Preparation
HSG - HSG Test -HSG Film Advice, Preparation
{{Medical imaging
Projectional radiography
Female genital procedures