Hydroxyethylrutosides (oxerutins, ''O''-beta-hydroxyethyl-rutosides, HR, or HER) are hydroxyethyl derivatives of rutosides. Examples include: * Monoxerutin * Dihydroxyethylrutoside * Troxerutin * Tetrahydroxyethylrutoside Oxerutins are semisynthetic derivatives of plant constituents. Although they are closely related to the natural flavonoid rutin, hydroxyethylrutosides are not found in food. The only way to take them is in a supplement.

Health benefits

Relvène (1967 French version), Venoruton (1962 Swiss version), and Paroven are mixtures of hydroxyethyl rutinosides. Hydroxyethylrutosides are used in the treatment of

chronic venous insufficiency Chronic venous insufficiency (CVI) is a medical condition characterized by blood pooling in the veins, leading to increased pressure and strain on the vein walls. The most common cause of CVI is superficial venous reflux, which often results in ...

and hypertensive microangiopathy. Oxerutins work by reducing leakage from the small blood vessels (capillaries). Hydroxyethylrutosides have been used as an alternative to horse chestnut preparations ( venostasin) containing aescin. Typical doses are in the order of 1,000 mg/day. Effects of hydroxyethylrutosides against adriamycin-induced toxicity have been investigated in rats.

References

{{Vasoprotectives Quercetin glycosides Flavonol rutinosides