The human identical sequence (HIS) is a sequence of RNA elements, 24-27

nucleotide Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecul ...

s in length, that coronavirus genomes share with the human genome. In pathogenic progression, HIS acts as a NamiRNA (nuclear activating miRNA) through the NamiRNA- enhancer network to activate neighboring host genes. The first HIS elements was identified in the

SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a No ...

genome, which has five HIS elements; other human coronaviruses have one to five. It has been suggested that these sequences can be more generally termed "host identical sequences" since similar correlations have been found between the genome of SARS-CoV-2 and multiple potential hosts ( bats, pangolins, ferrets, and cats).

SARS-CoV-2

SARS-CoV-1

MERS-CoV

HCoV-HKU1

HCoV-NL63

HCoV-OC43

HCoV-229E

References