Horace Albert "Nook" Barker (November 29, 1907 – December 24, 2000) was an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological che ...

and

microbiologist A microbiologist (from Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of microscopic organisms such as bacteria, algae, fungi, and some types of par ...

who studied the operation of biological and chemical processes in plants, humans and other animals, including using

radioactive tracer A radioactive tracer, radiotracer, or radioactive label is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by t ...

s to determine the role

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...

s play in synthesizing

sucrose Sucrose, a disaccharide, is a sugar composed of glucose and fructose subunits. It is produced naturally in plants and is the main constituent of white sugar. It has the molecular formula . For human consumption, sucrose is extracted and refi ...

. He was recognized with the

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

for his role in identifying an active form of Vitamin B₁₂.

Early life and education

Barker was born on November 29, 1907, in

Oakland, California Oakland is the largest city and the county seat of Alameda County, California, United States. A major West Coast of the United States, West Coast port, Oakland is the largest city in the East Bay region of the San Francisco Bay Area, the third ...

. He moved with his family to

Palo Alto, California Palo Alto (; Spanish for "tall stick") is a charter city in the northwestern corner of Santa Clara County, California, United States, in the San Francisco Bay Area, named after a coastal redwood tree known as El Palo Alto. The city was ...

when he was 11 years old. He spent a year in Germany following high school, learning the

German language German ( ) is a West Germanic language mainly spoken in Central Europe. It is the most widely spoken and official or co-official language in Germany, Austria, Switzerland, Liechtenstein, and the Italian province of South Tyrol. It is als ...

and absorbing its culture. He attended Stanford University, graduating in 1929 with a bachelor's degree in

physical science Physical science is a branch of natural science that studies non-living systems, in contrast to life science. It in turn has many branches, each referred to as a "physical science", together called the "physical sciences". Definition Phys ...

, and was awarded a

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...

in chemistry in 1933.Ballou, Clinton E
"Horace Albert Barker, Biochemistry: Berkeley"

University of California The University of California (UC) is a public land-grant research university system in the U.S. state of California. The system is composed of the campuses at Berkeley, Davis, Irvine, Los Angeles, Merced, Riverside, San Diego, San Fran ...

. Accessed July 20, 2009. After graduating from Stanford, he performed a two-year postgraduate fellowship at the

Hopkins Marine Station Hopkins Marine Station is the marine laboratory of Stanford University. It is located ninety miles south of the university's main campus, in Pacific Grove, California (United States) on the Monterey Peninsula, adjacent to the Monterey Bay Aquar ...

under the supervision of

C. B. van Niel, who fostered Barker's interest in botany and taught him techniques for isolating microorganisms. He then spent a year at the Delft Microbiology Laboratory in the

Netherlands ) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherl ...

under Albert Kluyver.

University of California

Barker was hired in 1936 by the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

to teach soil microbiology. He was part of a team that developed the use of Carbon-14 as a radioactive tracer, using the technique in 1944 to show how sucrose is synthesized in living cells by enzymes. Research led by Barker during the 1950s provided insights into the uses of vitamin B₁₂ in the body using bacterium he had isolated from mud taken from

San Francisco Bay San Francisco Bay is a large tidal estuary in the United States, U.S. state of California, and gives its name to the San Francisco Bay Area. It is dominated by the big cities of San Francisco, San Jose, California, San Jose, and Oakland, Ca ...

. By 1959, through documenting the metabolic flow of the vitamin B₁₂ coenzyme, Barker was able to show its role in the body, helping to explain various diseases, such as

pernicious anemia Pernicious anemia is a type of vitamin B12 deficiency anemia, a disease in which not enough red blood cells are produced due to the malabsorption of vitamin B12. Malabsorption in pernicious anemia results from the lack or loss of intrinsic fac ...

, one of a series of conditions resulting from

vitamin B₁₂ deficiency A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an essential micronutrient that an organism needs in small quantities for the proper functioning of its metabolism. Essential nutrien ...

. In a

White House The White House is the official residence and workplace of the president of the United States. It is located at 1600 Pennsylvania Avenue Northwest, Washington, D.C., NW in Washington, D.C., and has been the residence of every U.S. preside ...

ceremony held on January 17, 1969,

U.S. President The president of the United States (POTUS) is the head of state and head of government of the United States of America. The president directs the Federal government of the United States#Executive branch, executive branch of the Federal gove ...

Lyndon Johnson awarded Barker with the

" r his profound study of the chemical activities of microorganisms, including the unraveling of fatty acid metabolism and the discovery of the active coenzyme form of vitamin B₁₂."The President's National Medal of Science: Recipient Details - H.A. Barker

National Science Foundation The National Science Foundation (NSF) is an independent agency of the United States government that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is the National ...

. Accessed July 20, 2009. When the department of biochemistry was established in 1959, he was named as a professor there. He served as the department's chairman in the 1960s, and continued work there for more than a decade after retiring in 1975 when he became an

emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...

professor. In 1953, he was elected a member of the

United States National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

. He was elected a Fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, ...

in 1967.

Personal

A resident of

Berkeley, California Berkeley ( ) is a city on the eastern shore of San Francisco Bay in northern Alameda County, California, United States. It is named after the 18th-century Irish bishop and philosopher George Berkeley. It borders the cities of Oakland and Emer ...

, Barker died at age 93 on December 24, 2000, due to

heart failure Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome, a group of signs and symptoms caused by an impairment of the heart's blood pumping function. Symptoms typically include shortness of breath, excessive fatigue, ...

at his home there. He had been married for 62 years to his wife, the former Margaret McDowell, at the time of her death in 1995.Saxon, Wolfgang
"Horace Barker, 93, Scientist Who Studied Body Chemistry"
''

The New York Times ''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid ...

'', January 10, 2001. Accessed July 20, 2009.

References

Research resources

Horace Albert Barker Papers, 1933-1992

The Bancroft Library The Bancroft Library in the center of the campus of the University of California, Berkeley, is the university's primary special-collections library. It was acquired from its founder, Hubert Howe Bancroft, in 1905, with the proviso that it retai ...

External links

National Academy of Sciences Biographical Memoir
{{DEFAULTSORT:Barker, Horace 1907 births 2000 deaths American biochemists American microbiologists Fellows of the American Academy of Arts and Sciences Members of the United States National Academy of Sciences National Medal of Science laureates People from Berkeley, California People from Oakland, California Stanford University alumni University of California, Berkeley College of Letters and Science faculty