Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an
enzyme that in humans is encoded by the ''HINT1''
gene.
HINT1 hydrolyzes purine nucleotide
phosphoramidates with a single phosphate group.
In addition, functions as scaffolding protein that modulates transcriptional activation.
It is a
haploinsufficient tumor suppressor gene that inhibits the
Wnt/β-catenin pathway in colon cancer cells and
microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the ''MITF'' gene.
MITF is a basic helix-loop-helix leucine zipper transcription factor ...
(MITF) activity in human mast cells.
In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by
diadenosine tetraphosphate (Ap4A), produced by
LysRS.
See also
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Histidine triad nucleotide-binding protein 2
Histidine triad nucleotide binding protein 2 (HINT2) is a mitochondrial protein that in humans is encoded by the ''HINT2'' gene on chromosome 9. This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression.
...
(HINT2)
References
Further reading
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