Hispidulin is a naturally occurring

flavone Flavone is an organic compound with the formula . A white solid, flavone is a derivative of chromone with a phenyl (Ph) substituent adjacent to the ether group. The compound is of little direct practical importance, but susbstituted derivatives, t ...

with potential

antiepileptic Anticonvulsants (also known as antiepileptic drugs or recently as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of b ...

activity in rats and gerbils.The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects, Dominique Kavvadias et al, British Journal of Pharmacology (2004) 142, 811–820 It is found in plants including ''

Grindelia argentina ''Grindelia'' (gumweed) is a genus of plants native to the Americas belonging to the family Asteraceae. The genus was named for Latvian botanist David Hieronymus Grindel, 1776–1836. They are herbaceous plants or subshrubs with annual, bienni ...

'', '' Arrabidaea chica'', ''

Saussurea involucrate ''Saussurea'' is a genus of about 300 species of flowering plants in the tribe Cardueae within the family Asteraceae, native to cool temperate and arctic regions of East Asia, Europe, and North America, with the highest diversity in alpine ...

'', ''

Crossostephium chinense ''Crossostephium'' is a monotypic genus of flowering plants in the family Asteraceae. The only species is ''Crossostephium chinense'' native to parts of Japan ( Kazan-retto, Nansei-shoto), Taiwan, Guangdong, Indochina, Peninsular Malaysia, ...

'', '' Artemisia'', and ''

Salvia ''Salvia'' () is the largest genus of plants in the sage family Lamiaceae, with nearly 1000 species of shrubs, herbaceous perennials, and annuals. Within the Lamiaceae, ''Salvia'' is part of the tribe Mentheae within the subfamily Nepetoide ...

''.

Complementary medicine

In traditional and complementary medicine it is claimed to have "antioxidant, antifungal, anti-inflammatory, antimutagenic, and antineoplastic properties".Kanika Patel, Dinesh Kumar Patel, Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report, Journal of Traditional and Complementary Medicine, 2016, ISSN 2225-4110, https://dx.doi.org/10.1016/j.jtcme.2016.11.003.

Notes

Anticonvulsants O-methylated flavones Flavones GABAA receptor positive allosteric modulators {{aromatic-stub