Hispidulin is a naturally occurring
flavone
Flavone is an organic compound with the formula . A white solid, flavone is a derivative of chromone with a phenyl (Ph) substituent adjacent to the ether group. The compound is of little direct practical importance, but substituted derivatives, ...
with potential
antiepileptic
Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also used in the treatmen ...
activity in rats and gerbils.
[The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects, Dominique Kavvadias et al, British Journal of Pharmacology (2004) 142, 811–820] It is found in plants including ''
Grindelia argentina'', ''
Arrabidaea chica'', ''
Saussurea involucrate'', ''
Crossostephium chinense'', ''
Artemisia'', and ''
Salvia
''Salvia'' () is the largest genus of plants in the sage family Lamiaceae, with just under 1,000 species of shrubs, Herbaceous plant, herbaceous Perennial plant, perennials, and Annual plant, annuals. Within the Lamiaceae, ''Salvia'' is part o ...
''.
[
]
Complementary medicine
In traditional and complementary medicine it is claimed to have "antioxidant, antifungal, anti-inflammatory, antimutagenic, and antineoplastic properties".[Kanika Patel, Dinesh Kumar Patel, Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report, Journal of Traditional and Complementary Medicine, 2016, ISSN 2225-4110, https://dx.doi.org/10.1016/j.jtcme.2016.11.003.]
Notes
Anticonvulsants
O-methylated flavones
Flavones
GABAA receptor positive allosteric modulators
Triols
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