The HUGO Gene Nomenclature Committee (HGNC) is a committee of the

Human Genome Organisation The Human Genome Organisation (HUGO) is a non-profit organization founded in 1988. HUGO represents an international coordinating scientific body in response to initiatives such as the Human Genome Project. HUGO has four active committees, includi ...

(HUGO) that sets the

standards Standard may refer to: Symbols * Colours, standards and guidons, kinds of military signs * Standard (emblem), a type of a large symbol or emblem used for identification Norms, conventions or requirements * Standard (metrology), an object t ...

for human

gene nomenclature Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms. It is also closely associated with protein nomenclature, as genes and the proteins they code for usually have similar nomenclature. An international co ...

. The HGNC approves a ''unique'' and ''meaningful'' name for every known human

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

, based on a query of experts. In addition to the name, which is usually 1 to 10 words long, the HGNC also assigns a symbol (a short group of characters) to every gene. As with an SI symbol, a gene symbol is like an abbreviation but is more than that, being a second unique name that can stand on its own just as much as substitute for the longer name. It may not necessarily "stand for" the initials of the name, although many gene symbols do reflect that origin.

Purpose

Full gene names, and especially gene abbreviations and symbols, are often not specific to a single gene. A marked example is CAP which can refer to any of 6 different genes (
BRD4
'',
CAP1
'',
HACD1
'',
LNPEP
'',
SERPINB6
'', and
SORBS1
''). The HGNC short gene names, or gene symbols, unlike previously used or published symbols, are specifically assigned to one gene only. This can result in less common abbreviations being selected but reduces confusion as to which gene is referred to.

Naming guidelines

The HGNC published its latest human gene naming guidelines in 2020. These may be summarized as: # ''gene symbols must be unique'' # symbols should only contain

Latin letters The Latin script, also known as the Roman script, is a writing system based on the letters of the classical Latin alphabet, derived from a form of the Greek alphabet which was in use in the ancient Greek city of Cumae in Magna Graecia. The Gree ...

and

Arabic numerals The ten Arabic numerals (0, 1, 2, 3, 4, 5, 6, 7, 8, and 9) are the most commonly used symbols for writing numbers. The term often also implies a positional notation number with a decimal base, in particular when contrasted with Roman numera ...

# symbols should not contain

punctuation Punctuation marks are marks indicating how a piece of writing, written text should be read (silently or aloud) and, consequently, understood. The oldest known examples of punctuation marks were found in the Mesha Stele from the 9th century BC, c ...

or "G" for gene # symbols do not contain any reference to the

species A species () is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can produce fertile offspring, typically by sexual reproduction. It is the basic unit of Taxonomy (biology), ...

they are encoded in, i.e. "H/h" for human The HGNC states that "gene nomenclature should ''evolve with new technology'' rather than be restrictive, as sometimes occurs when historical and single gene nomenclature systems are applied." The HGNC has also issued guides to specific locus types such as endogenous retroviral loci, structural variants and non-coding RNAs.

Naming procedure

When assigning new gene nomenclature the HGNC make efforts to contact authors who have published on the human gene in question by email, and their responses to the proposed nomenclature are requested. HGNC also coordinates with the related Mouse and Rat Genomic Nomenclature Committees, other database curators, and experts for given specific gene families or sets of genes.

Revision

The gene name revision procedure is similar to the naming procedure, but changing a standardized gene name after establishment of a consensus can create confusion, therefore the merit of this is controversial. For this reason the HGNC aims to change a gene name only if agreement for that change can be reached among a majority of researchers working on that gene.

References

External links