Heterogonesis describes the segregation of parental genomes into distinct cell lineages in the dividing

zygote A zygote (; , ) is a eukaryote, eukaryotic cell (biology), cell formed by a fertilization event between two gametes. The zygote's genome is a combination of the DNA in each gamete, and contains all of the genetic information of a new individ ...

Fertilisation Fertilisation or fertilization (see spelling differences), also known as generative fertilisation, syngamy and impregnation, is the fusion of gametes to give rise to a zygote and initiate its development into a new individual organism or of ...

occurs when an

ovum The egg cell or ovum (: ova) is the female reproductive cell, or gamete, in most anisogamous organisms (organisms that reproduce sexually with a larger, female gamete and a smaller, male one). The term is used when the female gamete is not capa ...

fuses with a

sperm Sperm (: sperm or sperms) is the male reproductive Cell (biology), cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Animals produce motile sperm ...

, forming a

. Normally, the

genome A genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as ...

s of the two parents assort into two

diploid Ploidy () is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes. Here ''sets of chromosomes'' refers to the number of maternal and paternal chromosome copies, ...

bi-parental daughter cells. In a heterogoneic cell division, the genome of only one parent assorts into a single daughter cell following the formation of a tripolar (rather than the normal bipolar)

spindle apparatus In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter Cell (biology), cells. It is referred to as the mitotic spindle during mitos ...

. Heterogonesis allows for chromosomal segregation to occur in a dispermic fertilisation which may subsequently result in

chimerism A genetic chimerism or chimera ( or ) is a single organism composed of cells of different genotype, genotypes. Animal chimeras can be produced by the fusion of two (or more) embryos. In plants and some animal chimeras, Mosaic (genetics), mos ...

or sesquizygosis. The term heterogonesis was coined in 2016 by Destouni and Vermeesch who observed the phenomenon in

bovine Bovines (subfamily Bovinae) comprise a diverse group of 10 genera of medium to large-sized ungulates, including Bos, cattle, bison, African buffalo, Bubalus, water buffalos, and the four-horned and spiral-horned antelopes. The members of this gro ...

zygotes. The word is derived from the Greek meaning "different parental origin".

References

{{reflist Cell anatomy Chimerism Developmental biology Genetics concepts Mitosis Reproduction