Hermann A. M. Mucke (born 4 September 1955) is an Austrian bioscientist with a peer-review publishing record in the fields of

molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

neuropsychiatry Neuropsychiatry is a branch of medicine that deals with psychiatry as it relates to neurology, in an effort to understand and attribute behavior to the interaction of neurobiology and social psychology factors. Within neuropsychiatry, the mind i ...

cardiology Cardiology () is the study of the heart. Cardiology is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery di ...

and

ophthalmology Ophthalmology (, ) is the branch of medicine that deals with the diagnosis, treatment, and surgery of eye diseases and disorders. An ophthalmologist is a physician who undergoes subspecialty training in medical and surgical eye care. Following a ...

, mostly from the perspective of

drug development Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regu ...

. He is also a

management consultant Management consulting is the practice of providing consulting services to organizations to improve their performance or in any way to assist in achieving organizational objectives. Organizations may draw upon the services of management consultant ...

and entrepreneur working and publishing in biopharmaceutical strategic

knowledge management Knowledge management (KM) is the set of procedures for producing, disseminating, utilizing, and overseeing an organization's knowledge and data. It alludes to a multidisciplinary strategy that maximizes knowledge utilization to accomplish organ ...

intellectual property Intellectual property (IP) is a category of property that includes intangible creations of the human intellect. There are many types of intellectual property, and some countries recognize more than others. The best-known types are patents, co ...

management, and life science

technology assessment Technology assessment (TA, , ) is a practical process of determining the value of a new or emerging technology in and of itself or against existing technologies. This is a means of assessing and rating the new technology from the time when it w ...

Academic career

Hermann Mucke attended the

University of Vienna The University of Vienna (, ) is a public university, public research university in Vienna, Austria. Founded by Rudolf IV, Duke of Austria, Duke Rudolph IV in 1365, it is the oldest university in the German-speaking world and among the largest ...

where he obtained his master and Ph.D. degrees in biochemistry. This earliest plant molecular biology phase of Mucke's work concerned the characterization and partial sequencing of the ''

Cyanophora ''Cyanophora'' is a genus of glaucophytes, a group of rare but evolutionarily significant freshwater microalgae. It includes the following species: * '' Cyanophora biloba'' * '' Cyanophora cuspidata'' * '' Cyanophora kugrensii'' * '' Cyanophora ...

'' cyanelle genome, believed to resemble early stages of chloroplast evolution according to the

endosymbiotic theory Symbiogenesis (endosymbiotic theory, or serial endosymbiotic theory) is the leading evolutionary theory of the origin of eukaryotic cells from prokaryotic organisms. The theory holds that mitochondria, plastids such as chloroplasts, and possibl ...

Industry research executive

After leaving the university Mucke became executive director of research and development at an Austrian pharmaceutical company. He developed an indirect

immunofluorescence Immunofluorescence (IF) is a light microscopy-based technique that allows detection and localization of a wide variety of target biomolecules within a cell or tissue at a quantitative level. The technique utilizes the binding specificity of anti ...

assay for the detection of antibodies to the

human immunodeficiency virus The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause AIDS, acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of th ...

in human body fluids which was approved under the name Fluorognost(TM) HIV-1 by the U.S. FDA approval on 5 February 1992. A

human T-lymphotropic virus The primate T-lymphotropic viruses (PTLVs) are a group of retroviruses that infect primates, using their lymphocytes to reproduce. The ones that infect humans are known as human T-lymphotropic virus (HTLV), and the ones that infect Old World monk ...

antibody test, developed by Mucke's team but never marketed, served to demonstrate the first evidence of retrovirus-like serological reactivity in patients with the

myelodysplastic syndrome A myelodysplastic syndrome (MDS) is one of a group of cancers in which blood cells in the bone marrow do not mature, and as a result, do not develop into healthy blood cells. Early on, no symptoms typically are seen. Later, symptoms may includ ...

, a finding that meanwhile has been corroborated on the genomic level. In 1994 Mucke developed a new research focus in neuropsychiatry, initially with a focus on

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...

and related

neurodegenerative diseases A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration. Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, mul ...

. He directed an R&D program for

galantamine Galantamine is a type of acetylcholinesterase inhibitor. It is an alkaloid extracted from the bulbs and flowers of ''Galanthus nivalis'' (common snowdrop), '' Galanthus caucasicus'' (Caucasian snowdrop), '' Galanthus woronowii'' (Voronov's snow ...

derivatives. Soon thereafter he began to cooperate with various pharmaceutical intelligence providers and publishers in the United States and the United Kingdom, both as an author and as a contributing editor.

Industry advisor and publisher

When in 2000 Mucke resigned his executive function in the pharmaceutical industry to set up his own consulting enterprise, the financial newspaper

WirtschaftsBlatt ''WirtschaftsBlatt'' (meaning ''The Business Journal'' in English) was the only daily financial newspaper published in Vienna, the Republic of Austria.Business Press EuropeWirtschaftsBlatt ProfileRetrieved 30 May 2012 The newspaper appeared every ...

took note of the fact. Since this time he has been an independent scientific advisor to life science companies and a prolific author of market and technology reports. He continues to publish his own original scientific research and commissioned reviews both in commercial and

open access Open access (OA) is a set of principles and a range of practices through which nominally copyrightable publications are delivered to readers free of access charges or other barriers. With open access strictly defined (according to the 2001 de ...

peer-review journals. His most recent papers demonstrate a systematic utilization of

patent A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an sufficiency of disclosure, enabling discl ...

documents as a source of information in science, technology, and market research in the fields of

, renal and cardiorespiratory medicine, especially

pulmonary hypertension Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure in the pulmonary artery, arteries of the lungs. Symptoms include dypsnea, shortness of breath, Syncope (medicine), fainting, tiredness, chest pain, pedal edema, swell ...

, and endothelin receptor antagonists. By 2009 Hermann Mucke had authored or co-authored about 50 peer reviewed original research papers and invited reviews, in addition to dozens of drug evaluations. He is also a coinventor on several patent families which concern themselves with the pharmacotherapy of

alcohol abuse Alcohol abuse encompasses a spectrum of alcohol-related substance abuse. This spectrum can range from being mild, moderate, or severe. This can look like consumption of more than 2 drinks per day on average for men, or more than 1 drink per ...

nicotine dependence Nicotine dependence is a state of substance dependence on nicotine. It is a Chronic condition, chronic, relapsing disease characterized by a Compulsive behavior, compulsive craving to use the drug despite social consequences, loss of control over ...

, and depression. Hermann Mucke is Patent Editor at the

Thomson Reuters Thomson Reuters Corporation ( ) is a Canadian multinational corporation, multinational content-driven technology Conglomerate (company), conglomerate. The company was founded in Toronto, Ontario, Canada, and maintains its headquarters at 1 ...

journal, ''Current Opinion in Investigational Drugs'' and an advisor to the Antiviral Spot of Excellence Vienna (ASPEX). He is frequently interviewed by media covering the pharmaceutical industry, mostly on issues concerning the streamlining of drug development through optimization of clinical trials, new approaches to the clinical trial process, or medical imaging.Ward J: From Mice to Men: Is Imaging the Magic Pill for Faster Drug Development? ADVANCE for Imaging & Radiation Oncology. February 23, 2005
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References

External links

*Peer-reviewed papers by Hermann A.M. Mucke in PubMe
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*Papers by Hermann A. M. Mucke in Google Schola
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*Literature-based profile for Hermann A.M. Mucke at BiomedExpertsbr>Dynamic query
{{DEFAULTSORT:Mucke, Hermann (Bioscientist) Austrian technology writers Consultants Austrian biochemists Austrian neuroscientists 1955 births Living people