The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an
RNA element which is found in the coding region of the
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...
NS5B. Mutations in this family have been found to cause a blockage in
RNA replication
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...
and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.
See also
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Hepatitis C alternative reading frame stem-loop
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Hepatitis C virus 3'X element
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Hepatitis C virus stem-loop VII
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Hepatitis C stem-loop IV
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Hepatitis C
Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, ...
References
External links
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Cis-regulatory RNA elements
Hepatitis C virus
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