The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an
RNA element which is found in the coding region of the
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the self-replication, replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand Complementarity (molecular biology), compleme ...
NS5B
Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). It is an RNA-dependent RNA polymerase, having the key function of replicating HCV's viral RNA by using the viral positive RNA strand as a template to catalyze ...
. Mutations in this family have been found to cause a blockage in
RNA replication
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to ...
and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.
See also
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Hepatitis C alternative reading frame stem-loop
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Hepatitis C virus 3'X element
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Hepatitis C virus stem-loop VII
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Hepatitis C stem-loop IV
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Hepatitis C
Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection period, people often have mild or no symptoms. Early symptoms can include ...
References
External links
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Cis-regulatory RNA elements
Hepatitis C virus
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