The Hepatitis B virus PRE stem-loop alpha (HBV PRE SL alpha) is an
RNA structure
Nucleic acid structure refers to the structure of nucleic acids such as DNA and RNA. Chemically speaking, DNA and RNA are very similar. Nucleic acid structure is often divided into four different levels: primary, secondary, tertiary, and quaterna ...
that is shown to play a role in nuclear export of
HBV mRNAs.
HBV PREalpha consists of a 30
nt stem-loop, with a 5 nt apical loop. The conserved
stem-loop
Stem-loops are nucleic acid Biomolecular structure, secondary structural elements which form via intramolecular base pairing in single-stranded DNA or RNA. They are also referred to as hairpins or hairpin loops. A stem-loop occurs when two regi ...
was predicted within the HBV PRE sequence and confirmed by
mutagenesis
Mutagenesis () is a process by which the genetic information of an organism is changed by the production of a mutation. It may occur spontaneously in nature, or as a result of exposure to mutagens. It can also be achieved experimentally using lab ...
.
The exact role of this structure in nuclear export has not yet been determined.
See also
*
Hepatitis B virus PRE beta
*
HBV RNA encapsidation signal epsilon
The HBV RNA encapsidation signal epsilonHBV_epsilon is an element essential for Hepatitis B virus, HBV virus replication.
It is an RNA structure situated near the 5' end of the Hepatitis B virus, HBV pregenomic RNA.
The structure consists of a l ...
*
Hepatitis_B virus PRE 1151–1410
Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element. However, the function is ...
References
Cis-regulatory RNA elements
Hepatitis B virus
{{molecular-cell-biology-stub