Haifan Lin

Haifan Lin () is a Chinese-born American stem cell biologist. He is the Eugene Higgins Chair Professor of Cell Biology at Yale University and the founding Director of the Yale Stem Cell Center. He previously founded and directed the Stem Cell Research Program at Duke University. Recognized for his significant contributions to stem cell research, he was elected to the US National Academy of Sciences and American Academy of Arts and Sciences in 2018.

Biography

Lin was born in Dongtou, Wenzhou, Zhejiang, China. In 1982, he graduated from Fudan University in Shanghai with a bachelor's degree in biochemistry. He moved to the United States to pursue graduate studies at Cornell University and earned his PhD in 1990 in genetics and development. He subsequently worked as a Jane Coffin Childs Fellow for Medical Research at the Carnegie Institution for Science.

In 1994, he became a faculty member of Duke University School of Medicine, and later established the Stem Cell Research Program in 2005. In 2006, Lin moved to Yale University, where he founded the Yale Stem Cell Center and served as its director. He is also the Eugene Higgins Chair Professor of Cell Biology, Professor of Genetics, of Obstetrics, Gynecology, & Reproductive Sciences, and of Dermatology at Yale School of Medicine.

From 2014 to 2022, Lin served concurrently as the adjunct founding dean of ShanghaiTech University's School of Life Science and Technology in China, while retaining his positions at Yale.

Lin's work is focused on the self-renewing mechanism of stem cells, especially the small-RNA-mediated gene regulation mechanism. His research uses ''Drosophila'' germline stem cells, mouse germline stem cells, and mouse embryonic stem cells as models. He also studies germline development and stem cell-related cancers.

Lin is recognized for his contributions to stem cell and developmental biology research, especially for his discoveries of the Piwi/Argonaute (AGO) gene family and the Piwi-interacting RNAs (piRNAs), and for contributing to the demonstration of asymmetric stem cell division and to the proof of the stem cell niche theory. The journal ''Science'' named the discovery of piRNAs as one of the ten most important breakthroughs in 2006. In recent years, he demonstrated the crucial roles of the Piwi-piRNA pathway in epigenetic programming and post-transcriptional regulation of mRNA and lncRNA (see Select Bibliography).

Lin has played numerous leadership roles globally in the scientific community. He is President (2022-2023) of the International Society for Stem Cell Research (ISSCR) and has served as Director (2009-2019, 2020–present), Treasurer (2013-2016), Executive Committee Member, Vice President (2020-2021), and President-Elect (2021-2022) of ISSCR; Chair of the Finance Committee (2013-2016); Chair the Publications Committee (2009-2012), and Chair the Annual Meeting Program Committee (2010-2011) of the ISSCR. He led the establishment of ISSCR's official journal, ''Stem Cell Reports'' (2010-2012). 

Lin has also served on the Medical Advisory Board of New York Stem Cell Foundation (2009–present), the US National Institutes of Health (NIH) Director's Pioneer Award Selection Committee (2009), the NIH study sections (1998-2005, 2007, 2012, 2014, 2019–2020), the Board of Directors of the Society of Chinese Biological Investigators, USA (2002-2008), the Council of the Society of Chinese Bioscientists in America (2008-2011), the Advisory Council of RIKEN Center for Developmental Biology, Japan (2007-2015), the Scientific Advisory Board of the Jane Coffin Childs Memorial Fund for Medical Research (2011-2015), National Key Stem Cell Research Advisory Committee, Chinese Ministry of Science and Technology (2011-2014), the Council of Shantou University (2010-2015), and the Council of Connecticut Academy of Science and Engineering (2013-2016). He was a co-founder and Core Member of the Connecticut State Government Life Sciences Advisory Group (2011-2012) and served on the advisory board of Connecticut Innovation Bioscience Fund (2017-2020).

Honors

Academic Awards:

* The Chinese Association for Science and Technology, USA, Outstanding Science and Innovation Award, 2019.
* The Society for the Study of Reproduction Research Award, 2015.
* The G. Harold and Leila Y. Mathers Award, 2007, 2010, 2014.
* The Ray Wu Award (highest honor by the Chinese Biological Investigators Society, USA), 2013.
* The NIH MERIT Award, 2012.
* The NIH Director's Pioneer Award, 2010.
* The Ellison Medical Foundation Senior Scholar Award, 2010.
* Outstanding Fudan University Alumnus Award, North America Fudan Alumni Association, 2010.
* The Laura Hartenbaum Breast Cancer Foundation's Legacy for Hope Award, 2009.
* The American Society of Andrology Lecturer Award, 2008.
* The David and Lucile Packard Fellowship for Science and Engineering, 1996.
* American Cancer Society Junior Faculty Research Award, 1996.
* March of Dimes Basil O'Connor Scholar Research Award, 1996.
* The Jane Coffin Childs Fellow for Medical Research, 1990.
* Second Place, the Larry Sandler Memorial Award for the best Ph.D. thesis research in Genetics, Genetics Society of America, 1990.
* Sage Graduate Fellowship, Cornell University, 1989.
* The Wu Memorial Award, Cornell University; 1987.
* Fellowship (among top ten), the 1982 China and United States Biochemistry and Molecular Biology Examinations and Admissions (CUSBEA) Program.
* Inaugural Fudan University Scholarship; 1982.
* University-level Honors Student, Fudan University; 1980, 1981, and 1982.
* Honors Student, Fudan University; 1979.

Elected Memberships:
* Foreign Member, the Chinese Academy of Sciences in 2021.
* Member, the US National Academy of Sciences, 2018.
* Member, the American Academy of Arts and Sciences, 2018.
* Fellow, the American Association for the Advancement of Science, 2010.
* Member, Connecticut Academy of Science and Engineering, 2007.

China Initiative case

Lin was investigated by federal agencies under the Trump administration's China Initiative. The government's allegations against Lin remain unclear. He was not arrested or charged with any crime. Lin was temporarily suspended from Yale and banned from running his lab in January 2022.
In April 2022, the case was dropped by the Biden administration's Department of Justice and Yale lifted Lin's suspension.

There was an outpouring of support for Lin by Yale faculty members during his suspension, including: a March 9, 2022, letter addressed to Yale University President Peter Salovey, and signed by nearly 100 Yale professors calling for Lin's full reinstatement. In addition, on March 17, 2022, the Yale Department of Cell Biology and the Yale Stem Cell Center published a joint statement noting that "Haifan Lin is not only a brilliant scientist and mentor, whose eminence has been recognized by election to the US National Academy of Sciences, but also a leader who we know to be of the utmost integrity. We have complete confidence in him. We are equally confident that the Department of Justice investigation will only reveal that he has been the victim of poorly conceived federal policies."

Select Bibliography

* Cheng, E.C.*, Hsieh, C.L.*, Liu, N., Wang, J., Zhong, M. Chen, T., and Li, E., and Lin, H. (2021) The essential function of SetDB1 in homologous chromosome pairing and synapsis during meiosis. ''Cell Reports'' 34: 108575 (* co-first authors)
* Hsieh, C.L., Xia, J., Lin, H. (2020) MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA. ''The EMBO Journal'', 39:e103614.
* Uyhazi^, K., Yang, Y., Liu, N., Qi, H., Huang, X., Mak, W., Weatherbee, S., de Prisco, N., Gennarino, V. A., Song, X., and Lin, H. (2020) Pumilio Proteins Utilize Distinct Regulatory Mechanisms to Achieve Complementary Functions Required for Pluripotency and Embryogenesis. ''PNAS,'' 117: 7851–7862.
* Shi, S., Yang, Z.-Z., Liu, S. Yang, F. and Lin, H. (2020) PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. ''PNAS'', 117, 22390–22401.
* Watanabe, T., Cui, X., Yuan, Z., Qi, H. and Lin, H. (2018) MIWI2 targets RNA transcribed from piRNA-dependent regions for methylation in mouse prospermatogonia. ''EMBO Journal,'' 37:e95329.
* Zhang, M., Chen, D., Xia, J., Han, W., Hermes, G., Sestan, S., and Lin, H. (2017) Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins. ''Genes & Development'' 31, 1–16.
* Peng, J. C.^#,*, Anton Valouev, A.^#, Liu, N., and Lin^, H. ^*  (2016)  Piwi maintains germline stem cells and oogenesis in ''Drosophila'' through negative regulation of Polycomb group proteins. ''Nature Genetics'' 48, 283–291. (^# co-first authors; ^*co-corresponding authors)
* Wang, Z., Liu, N., Shi, S., Liu, S. and Lin, H. (2016) The Role of PIWIL4, an Argonaute family protein, in breast cancer. J. Biol. Chem. 291, 10646–10658. (Faculty 1000 Prime “Paper of Special Significance”)
* Watanabe, T., Cheng, E.-C., Zhong, M. Lin. H. (2015) Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline. ''Genome Research'' 25: 368–380.
* Juliano^, C. E., Reich, A., Liu, N., Uman, S., Wessel, G., W., Steele, R. E., and Lin, H. (2014) Analysis of the PIWI-piRNA pathway in ''Hydra'' somatic stem cells. ''PNAS'' 111, 337–342.
* Saxe, J. P., Chen, M., Zhao, H., and Lin, H. (2013) Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. ''EMBO J.'' 32, 1869–1885.
* Huang, X. A. ^*, Yin^*, H., Sweeney, S., Raha, D., Snyder, M. and Lin, H. (2013) A major epigenetic programming mechanism guided by piRNAs. ''Developmental Cell'' 24, 502-516 (^*co-first authors ; Featured Article)
* Beyret, E. and Lin, H. (2012) piRNA biogenesis in the adult mouse is independent of the ping-pong mechanism. ''Cell Research'' 22:1429-1439. (Cover call-out paper).
* Chen, D., Zheng, W. Lin, A., Uyhazi, K., Zhao, H., and  Lin, H.^. (2012) Pumilio 1 Suppresses Multiple Activators of p53 to Safeguard Spermatogenesis. ''Current Biology'' 22, 420–425.
* Gangaraju, V. K., Yin, H., Weiner, M. M., Wang, J., Huang, A. X., and Lin, H. (2010) ''Drosophila'' Piwi Functions in Hsp90-Mediated Suppression of Phenotypic Variation. ''Nature Genetics'' 43, 153–158.
* Szakmary, A., Mary Reedy, M., Qi, H.-Y., and Lin, H. (2009) The Yb protein localizes to a novel cytoplasmic structure and regulates germline stem cell division in both male and female ''Drosophila.''  ''J. Cell. Biol.'' 185:  613 - 627.
* Wang, J., Saxe, J. P., Tanaka, T., Chuma, S., and Lin, H. (2009) Mili interacts with Tudor Domain Containing Protein 1 (Tdrd1) in regulating spermatogenesis. ''Curr. Biol''. 19:640 - 644 (Cover story).
* Yin, H. and Lin, H. (2007) An epigenetic activation role of PIWI and a PIWI-associated piRNA in ''Drosophila melanogaster. Nature'' 450, 304–308.
* Brower-Toland, B*., Findley, S.*, Jiang, L., Liu, L., Dus, M., Zhou, P., Elgin, S., and Lin, H. (2007) ''Drosophila'' PIWI Associates with Chromatin and Interacts Directly with HP1a. ''Genes & Development'' 21: 2300-2311 (Cover story; * co-first authors)
* Megosh, H.*, Cox*, D. N., Chris Campbell, C. and Lin, H. (2006) The Role of PIWI and the miRNA machinery in ''Drosophila'' germline determination. ''Current Biology''. 16, 1884–1894 (*co-first authors).
* Grivna, S. T., Pyhtila, B. and Lin, H. (2006) MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis.  ''Proc. Natl. Acad. Sci.'' 103, 13415–13420. (cited as one of the Ten Breakthroughs of 2006 by ''Science'')
* Grivna, S. T. *, Beyret, E. *, Wang, Z. and Lin, H. (2006) A novel class of small RNAs in mouse spermatogenic cells''.  Genes & Development'' ''20'', 1709-1714 (*co-first authors; Cover call-out story; cited as one of the Ten Breakthroughs of 2006 by ''Science'')
* Wang, Z and Lin, H. (2004) nanos maintains germline stem cell self-renewal by preventing differentiation. ''Science'' 303, 2016–2019.
* Deng, W. and Lin, H. (2002) ''miwi'', a murine homolog of ''piwi'', encodes a cytoplasmic protein essential for spermatogenesis.  ''Developmental Cell'' 2, 819–830.
* King, F., J., Szakmary, A., Cox, D.N., and Lin, H. (2001) ''Yb'' modulates the division of both germline and somatic stem cells through ''piwi''- and ''hh''-mediated mechanisms in the ''Drosophila'' ovary.  ''Molecular Cell'' 7, 497–508.
* Cox, D. N., Chao, A., Baker, J., Chang, L., Qiao, D. and Lin, H. (1998).  A novel class of evolutionarily conserved genes defined by ''piwi'' are essential for stem cell self-renewal.  ''Genes & Development.'' 12, 3715–3727. over call-out story* Forbes, A., Spradling, A. C, Ingham, P., and Lin, H. (1996) The role of segment polarity genes during early oogenesis ''Drosophila''. ''Development'', 122, 3283–3294.
* Lin, H. and Spradling, A. C. (1997) A novel group of ''pumilio'' mutations affects the asymmetric division of germline stem cells in the ''Drosophila'' ovary. ''Development'', 124, 2463–2476.
* Lin, H. and Spradling, C. S. (1993) Germline Stem Cell Division and Egg Chamber Development in Transplanted Drosophila Germaria. ''Dev. Biol.'' 159, 140–152.
* Lin, H. and Wolfner, M. F. (1991) The ''Drosophila'' maternal effect gene ''fs(1)Ya'' encodes a cell cycle dependent nuclear envelope component required for embryonic mitoses. ''Cell'' 64, 49–62.

References

{{DEFAULTSORT:Lin, Haifan
Living people
Year of birth missing (living people)
Scientists from Wenzhou
Fudan University alumni
Cornell University alumni
Duke University faculty
Yale University faculty
Chinese emigrants to the United States
American molecular biologists
Chinese molecular biologists
Members of the United States National Academy of Sciences
American geneticists
Chinese geneticists
Stem cell researchers
Fellows of the American Association for the Advancement of Science
Educators from Wenzhou
Biologists from Zhejiang
Foreign members of the Chinese Academy of Sciences