HIV Tat-specific factor 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''HTATSF1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.
HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.
It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as
Nanog and
KLF2.
Interactions
HTATSF1 has been shown to
interact with
SUPT5H
Transcription elongation factor SPT5 is a protein that in humans is encoded by the ''SUPT5H'' gene.
Interactions
SUPT5H has been shown to interact with:
* CDK9,
* Cyclin-dependent kinase 7,
* HTATSF1,
* PIN1,
* POLR2A,
* PRMT1 and ...
and
GTF2F2
General transcription factor IIF subunit 2 is a protein that in humans is encoded by the ''GTF2F2'' gene.
Interactions
GTF2F2 has been shown to interact with POLR2E and HTATSF1.
See also
* Transcription Factor II F
Transcription factor ...
.
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References
Further reading
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