Non-histone chromosomal protein HMG-14 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''HMGN1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Chromosomal protein HMG14 and its close analog
HMG17 (MIM 163910) bind to the inner side of the
nucleosomal DNA, potentially altering the interaction between the DNA and the
histone octamer
In molecular biology, a histone octamer is the eight-protein complex found at the center of a nucleosome core particle. It consists of two copies of each of the four core histone proteins ( H2A, H2B, H3, and H4). The octamer assembles when a ...
. The 2 proteins may be involved in the process that maintains transcribable genes in a unique
chromatin
Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important r ...
conformation.
Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.
Interactions
HMGN1 has been shown to
interact with
YWHAZ
14-3-3 protein zeta/delta (14-3-3ΞΆ) is a protein that in humans is encoded by the ''YWHAZ'' gene on chromosome 8. The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction p ...
.
See also
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HMGN2
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High mobility group protein HMG14 and HMG17
References
Further reading
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