The HLA Informatics Group (HIG) is a research group led by Professor Steven Marsh at the

Anthony Nolan Anthony Nolan is a UK charity that works in the areas of leukaemia and hematopoietic stem cell transplantation. It manages and recruits donors to the Anthony Nolan Register, which is part of an aligned registry that also includes the ''Welsh Bon ...

Research Institute that develops, runs and maintains the IMGT (

immunogenetics Immunogenetics or immungenetics is the branch of Medical Immunology and Medical Genetics that explores the relationship between the immune system and genetics. Autoimmune diseases, such as type 1 diabetes, are complex genetic traits which res ...

)/HLA (

Human leukocyte antigen The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for the regulation of the immune system. The HLA system is also known as the human version of t ...

) Database and the IPD (immuno

polymorphism Polymorphism, polymorphic, polymorph, polymorphous, or polymorphy may refer to: Computing * Polymorphism (computer science), the ability in programming to present the same programming interface for differing underlying forms * Ad hoc polymorphis ...

database). The IMGT/HLA database originated as part of

IMGT IMGT or the international ImMunoGeneTics information system is a collection of databases and resources for immunoinformatics, particularly the V, D, J, and C gene sequences, as well as a providing other tools and data related to the adaptive imm ...

and was merged with IPD in 2003. The IMGT/HLA Database is a central repository for sequences of the human

major histocompatibility complex The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are call ...

and currently contains over 5,000

allele An allele (, ; ; modern formation from Greek ἄλλος ''állos'', "other") is a variation of the same sequence of nucleotides at the same place on a long DNA molecule, as described in leading textbooks on genetics and evolution. ::"The chro ...

sequences, including over 1,800

HLA-B HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) compl ...

sequences. As well as sequence information, the IMGT/HLA Database and the IPD Databases include extensive information regarding the source material that sequences are derived from.About the Databases
/ref> The IMGT/HLA website is the main source to know how many HLA alleles have been discovered.

References

External links

ANRI home page

HLA Informatics Group home page

IMGT/HLA database homepage

hla.alleles.org

IPD database homepage
Medical and health organisations based in the United Kingdom Bioinformatics organizations {{sci-org-stub