HLA-DR18 (DR18) is a HLA- DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

Serology

DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.

Disease associations

DR18 seropositivity is associated with rheumatoid polyarthritis DRB1*0302 is positively associated with

juvenile diabetes Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that occurs when the body's immune system destroys pancreatic cells (beta cells). In healthy persons, beta cells produce insulin. Insulin is a hormone required ...

, nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.

Genetic Linkage

HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.

References

{{DEFAULTSORT:Hla-Dr18 3