Guyer is a surname. Notable people with the surname include:
* Adolf Guyer-Zeller (1839–1899), Swiss entrepreneur
* Brandon Guyer (born 1986), American baseball player
* Charlie Guyer (1909–1977), Australian football player
* Cindy Guyer (born 1961), American model and actress
* Denis Guyer (born 1966), American politician
* Gino Guyer (born 1983), American ice hockey player
*
Gordon Guyer
Gordon Earl Guyer (30 May 1926 – 30 March 2016) was president of Michigan State University from 1992 to 1993. He died on March 30, 2016, aged 89.Irving Guyer (1916–2012), American painter
* Jane I. Guyer (born 1943), American anthropologist
* Josh Guyer (born 1994), Australian baseball player
* Léonie Guyer (born 1955), American artist
* Lisa Guyer (born 1963) American singer, guitarist, and songwriter
* Lux Guyer (1894–1955), Swiss architect
* Michael F. Guyer (1874–1959), American cytologist and zoologist
*
Murphy Guyer
Murphy Guyer (born December 25, 1952) is an American actor, playwright, writer and director, best known for his plays and for appearances in the films '' The Devil's Advocate'' (1997), '' The Jackal'' (1997), ''Arthur'' (2011) and '' Joker'' (2 ...
(born 1952), American actor, playwright, writer and director
*
Paul Guyer
Paul Guyer () is an American philosopher and a leading scholar of Immanuel Kant and of aesthetics. From 2012, he was Jonathan Nelson Professor of Philosophy and Humanities at Brown University until his retirement in 2023. In 2025, he was elected t ...
, American philosopher
* Percy Guyer, pseudonym of songwriter
Septimus Winner
Septimus Winner (May 11, 1827 – November 22, 1905) was an American songwriter of the 19th century. He used his own name, and also the pseudonyms Alice Hawthorne, Percy Guyer, Mark Mason, Apsley Street, and Paul Stenton. He was also a teacher ...
* Roy J. Guyer (1885–1956), American college athlete and coach
* Reyn Guyer (born 1935), American inventor of Twister
* Tennyson Guyer (1913–1981), American politician
* Thad McIntosh Guyer (born 1950), American civil rights lawyer
* U. S. Guyer (1868–1943), American politician from Kansas
Other uses
* Dowleh Guyer, a village in Iran
{{surname, Guyer