Gustav Georg Embden (10 November 1874 – 25 July 1933) was a German physiological chemist.

Background

Gustav Embden was a son of the Hamburg lawyer and politician George Heinrich Embden. His grandmother Charlotte Heine was a well-known salonnière and a sister of the poet

Heinrich Heine Christian Johann Heinrich Heine (; ; born Harry Heine; 13 December 1797 – 17 February 1856) was an outstanding poet, writer, and literary criticism, literary critic of 19th-century German Romanticism. He is best known outside Germany for his ...

Education and career

Embden initially studied in

Freiburg Freiburg im Breisgau or simply Freiburg is the List of cities in Baden-Württemberg by population, fourth-largest city of the German state of Baden-Württemberg after Stuttgart, Mannheim and Karlsruhe. Its built-up area has a population of abou ...

Strasbourg Strasbourg ( , ; ; ) is the Prefectures in France, prefecture and largest city of the Grand Est Regions of France, region of Geography of France, eastern France, in the historic region of Alsace. It is the prefecture of the Bas-Rhin Departmen ...

Munich Munich is the capital and most populous city of Bavaria, Germany. As of 30 November 2024, its population was 1,604,384, making it the third-largest city in Germany after Berlin and Hamburg. Munich is the largest city in Germany that is no ...

Berlin Berlin ( ; ) is the Capital of Germany, capital and largest city of Germany, by both area and List of cities in Germany by population, population. With 3.7 million inhabitants, it has the List of cities in the European Union by population withi ...

, and

Zurich Zurich (; ) is the list of cities in Switzerland, largest city in Switzerland and the capital of the canton of Zurich. It is in north-central Switzerland, at the northwestern tip of Lake Zurich. , the municipality had 448,664 inhabitants. The ...

under the famous physiologists of his time, including

Johannes von Kries Johannes Adolf von Kries (6 October 1853 – 30 December 1928) was a German physiological psychologist who formulated the modern “duplicity” or “duplexity” theory of vision mediated by rod cells at low light levels and three types of cone ...

Franz Hofmeister Franz Hofmeister (30 August 1850, in Prague – 26 July 1922, in Würzburg) was an early protein scientist, and is famous for his studies of salts that influence the solubility and conformational stability of proteins. In 1902, Hofmeister became t ...

, Gaule,

Paul Ehrlich Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology and antimicrobial chemotherapy. Among his foremost achievements were finding a cure fo ...

, and Julius Richard Ewald. In 1904, he became the director of the chemistry laboratory of the medical clinic at the Frankfurt-Sachsenhausen municipal hospital. His research here helped to build the clinic into the Physiological Institute by 1907 and into the University Institute for Vegetative Physiology in 1914. In the same year, he retained his directorship and started teaching at the

University of Frankfurt am Main Goethe University Frankfurt () is a public research university located in Frankfurt am Main, Germany. It was founded in 1914 as a citizens' university, which means it was founded and funded by the wealthy and active liberal citizenry of Frankfurt ...

. Embden served as the rector of the university from 1925 to 1926.

Research

Embden conducted studies on

carbohydrate metabolism Carbohydrate metabolism is the whole of the biochemistry, biochemical processes responsible for the metabolic anabolism, formation, catabolism, breakdown, and interconversion of carbohydrates in life, living organisms. Carbohydrates are central t ...

and

muscle contraction Muscle contraction is the activation of Tension (physics), tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in musc ...

, and he was the first to discover and link together all the steps involved in the conversion of

glycogen Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, fungi, and bacteria. It is the main storage form of glucose in the human body. Glycogen functions as one of three regularly used forms ...

lactic acid Lactic acid is an organic acid. It has the molecular formula C3H6O3. It is white in the solid state and it is miscible with water. When in the dissolved state, it forms a colorless solution. Production includes both artificial synthesis as wel ...

. In 1918,

Otto Fritz Meyerhof Otto Fritz Meyerhof (; 12 April 1884 – 6 October 1951) was a German physician and biochemist who won the 1922 Nobel Prize in Physiology and Medicine. Biography Otto Fritz Meyerhof was born in Hannover, at Theaterplatz 16A (now:Rathenaustrasse ...

's work on cellular

metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

showed that the process involved the breakdown of

glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...

to lactic acid. Embden is known for having worked out the precise steps involved in this breakdown. Henceforth, this cellular metabolic sequence from glycogen to lactic acid became known as the Embden–Meyerhof pathway. Embden had also worked on developing a technique to prevent tissue damage. In doing so, he discovered the

liver The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of var ...

's role in metabolic processes, thereby laying a foundation for understanding normal sugar metabolism and of its pathological form,

diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...

. Some scientific historians, such as Thomas Kuhn, consider the work done in the 1930s in the laboratories of Meyerhof, Parnas, Embden,

Warburg Warburg (; Westphalian: ''Warberich'' or ''Warborg'') is a town in eastern North Rhine-Westphalia, central Germany on the river Diemel near the three-state point shared by Hessen, Lower Saxony and North Rhine-Westphalia. It is in Höxter distr ...

, etc. to be the mark of a true scientific revolution.

Awards

Although Embden was never awarded a

Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...

, he was nominated 12 times over 8 years.

References

1874 births 1933 deaths 20th-century German chemists People educated at the Wilhelm-Gymnasium (Hamburg) Scientists from Hamburg Academic staff of Goethe University Frankfurt Members of the Royal Society of Sciences in Uppsala {{Germany-chemist-stub