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Guanoclor (
INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway. Before the advent of motorized transportation, they also provided accomm ...
), also known as guanochlor, is a
sympatholytic A sympatholytic (sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS). They are indicated for various functions; for example, t ...
drug. It is known to bind to non-adrenergic sites in pig kidney membranes.


Synthesis

When β-(2,6-dichlorophenoxy)ethyl bromide (1) is reacted with hydrazine to give 2, and this is reacted with S-methylthiourea, guanochlor (3) results.Prepn of free base and sulfate: (1963 to
Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...
), C.A. 60, 14437d (1964).


References

Abandoned drugs Adrenergic release inhibitors Antihypertensive agents Chloroarenes Aminoguanidines Phenol ethers {{Antihypertensive-stub