Gossypetin, also known as 3,5,7,8,3',4'-hexahydroxyflavone, is a flavonol, a type of

flavonoid Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids ...

. It has been isolated from the flowers and the calyx of '' Hibiscus sabdariffa'' (roselle) and exhibits a strong

antibacterial An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention ...

activity. The compound has also been found to act as an

antagonist An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.TrkB Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the ''NTRK2'' gene. TrkB is a recept ...

. Gossypetin has radioprotective activity. The enzyme 8-hydroxyquercetin 8-''O''-methyltransferase uses ''S''-adenosyl methionine and gossypetin to produce ''S''-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8-methoxyflavone. In 2022, a study in an animal model using intragastric administration suggested that the flavonoid gossypetin facilitated the clearance of beta-amyloid in the brain and is a promising target for the study of treatments for Alzheimer's Disease by enhancing microglial phagocytic activity against Aβ.

References

Aromatase inhibitors Catechols Flavonols Hydroxyquinols TrkB antagonists Hexols {{Aromatic-stub

See also

References