Transmembrane BAX inhibitor motif-containing protein 4 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''TMBIM4''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.

Function

Human GAAP is a protein present in the Golgi that helps regulate

apoptosis Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...

, a form of programmed cell death. By regulating the fluxes of Ca⁺², an increase of GAAP can help prevent apoptosis. GAAP is also involved in promoting cell migration and has been identified as a novel Golgi cation channel. Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.

Function

See also

References

Further reading