The enzyme hydroxyacylglutathione hydrolase (EC 3.1.2.6, systematic name = ''S''-(2-hydroxyacyl)glutathione hydrolase)
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycl ...
the following reaction:
:''S''-(2-hydroxyacyl)glutathione + H
2O = glutathione + a 2-hydroxy carboxylate
This enzyme belongs to the family of
hydrolase
Hydrolase is a class of enzyme that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are es ...
s, specifically the class of thioester lyases. It is commonly known as glyoxalase II. It participates in
pyruvate metabolism
Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH3COCOO−, is an intermediate in several metabolic pathways throughout the cell.
Pyruvic aci ...
.
References
*
EC 3.1.2
Enzymes of known structure
{{3.1-enzyme-stub