In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:D-glyceraldehyde 3-phosphate + phosphate + NAD
+ 3-phospho-D-glyceroyl phosphate + NADH + H
+
The 3
substrates of this enzyme are
D-glyceraldehyde 3-phosphate,
phosphate, and
NAD+, whereas its 3
products are
3-phospho-D-glyceroyl phosphate,
NADH, and
H+. This enzyme participates in
glycolysis / gluconeogenesis.
Nomenclature
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The
systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate, phosphoglyceraldehyde dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase, NAD+-dependent glyceraldehyde phosphate dehydrogenase, glyceraldehyde phosphate dehydrogenase (NAD+), glyceraldehyde-3-phosphate dehydrogenase (NAD+), NADH-glyceraldehyde phosphate dehydrogenase, and glyceraldehyde-3-P-dehydrogenase.
References
Further reading
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EC 1.2.1
NADH-dependent enzymes
Enzymes of known structure
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