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Glutaconyl-CoA is an intermediate in the metabolism of
lysine Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. Lysine contains an α-amino group (which is in the protonated form when the lysine is dissolved in water at physiological pH), an α-carboxylic acid group ( ...
. It is an organic compound containing a coenzyme substructure, which classifies it as a fatty ester lipid molecule. Being a lipid makes the molecule hydrophobic, which makes it insoluble in water. The molecule has a molecular formula of , and a molecular weight 879.62 grams per mole. Glutaconyl-CoA is postulated to be the main toxin in glutaric aciduria type 1. In certain fermentative bacteria, glutaconyl-CoA decarboxylation is catalyzed by a Na+-dependent decarboxylase () and is coupled with Na+ ion translocation, which creates a sodium-motive force as an alternate energy source for these organisms.


See also

* Glutaconate CoA-transferase * Glutaconyl-CoA decarboxylase


References

Thioesters of coenzyme A {{organic-compound-stub