Glutaconyl-CoA is an intermediate in the metabolism of
lysine
Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. Lysine contains an α-amino group (which is in the protonated form when the lysine is dissolved in water at physiological pH), an α-carboxylic acid group ( ...
. It is an organic compound containing a coenzyme substructure, which classifies it as a fatty ester lipid molecule. Being a lipid makes the molecule hydrophobic, which makes it insoluble in water. The molecule has a molecular formula of , and a molecular weight 879.62 grams per mole.
Glutaconyl-CoA is postulated to be the main toxin in
glutaric aciduria type 1. In certain fermentative bacteria, glutaconyl-CoA decarboxylation is catalyzed by a
Na+-dependent decarboxylase () and is coupled with Na
+ ion translocation, which creates a
sodium-motive force as an alternate energy source for these organisms.
See also
*
Glutaconate CoA-transferase
*
Glutaconyl-CoA decarboxylase
References
Thioesters of coenzyme A
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