Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''DLGAP1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the
post-synaptic density.
Function
This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the
SHANK and
PSD-95 proteins, facilitating the assembly of the post-synaptic density of neurons.
Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.
Interactions
DLGAP1 has been shown to
interact with:
*
DLG1[
* ]DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the ''DLG4'' (discs large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MA ...
[
* DYNLL2][
* SHANK2][
The interaction with PSD95 and S-SCAM is mediated by the GUK domain]
References
Further reading
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{{gene-18-stub
Proteins