Giuseppe Guarnieri (April 20, 1856 – August 15, 1918) was an Italian physician. Dr. Guarnieri made his most famous discovery in

1892 In Samoa, this was the only leap year spanned to 367 days as July 4 repeated. This means that the International Date Line was drawn from the east of the country to go west. Events January * January 1 – Ellis Island begins processing imm ...

while examining thin tissue cells damaged by smallpox. He discovered small bodies of protein clusters that he mistook for

bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...

, but were actually clusters of viral proteins crucial in the replication of pox viruses. He named these protein masses ''Cytorrhyctes variolae'' ("the cell destroyer of smallpox") but they were eventually properly identified and named

Guarnieri bodies Orthopoxvirus inclusion bodies are aggregates of stainable protein produced by poxvirus virions in the cell nuclei and/or cytoplasm of epithelial cells in humans. They are important as sites of viral replication. Morphology Morphologically there ...

References

1856 births 1918 deaths 19th-century Italian physicians {{Italy-med-bio-stub