Genetically modified sperm (GM sperm) is
sperm
Sperm (: sperm or sperms) is the male reproductive Cell (biology), cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Animals produce motile sperm ...
that has undergone
genetic modification
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including th ...
for biomedical purposes, including the elimination of
genetic disease
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders are ...
s or
infertility
In biology, infertility is the inability of a male and female organism to Sexual reproduction, reproduce. It is usually not the natural state of a healthy organism that has reached sexual maturity, so children who have not undergone puberty, whi ...
. Although the procedure has been tested on animals such as fish, pigs, and rabbits, it remains relatively untested on humans. In the case of pigs, the goal of research is to inexpensively produce organs and supplement the shortage of donated human organs.
Although GM sperm has the potential to detect and treat genetic diseases, it will likely take many years for successful use in patients.
Process
In genetic modification, genes are inserted into living cells in order to change how proteins are created. A viral vector is often used to deliver the gene of interest to the chromosomes in the cell nucleus. Every daughter cell will reflect the genetic modification.
Applications
GM sperm is not frequently used in humans but has been extensively tested and studied in animals. This type of modification of the sperm, eggs, or early embryos is known as an Inheritable Genetic Modification. Because the genetic changes are passed onto future generations, Inheritable Genetic Modification is far more consequential than
somatic cell
In cellular biology, a somatic cell (), or vegetal cell, is any biological cell forming the body of a multicellular organism other than a gamete, germ cell, gametocyte or undifferentiated stem cell. Somatic cells compose the body of an organism ...
modifications.
Regulations
Genetic modification of sperm cells, as a type of germline gene transfer, is subject to federal regulation in the United States under the Recombinant DNA Advisory Committee of the National Institutes of Health, as well as the Food and Drug Administration. Regulation in the United States currently prohibits the application or research use of such technologies in humans, but does allow for research and commercial use, prior to approval, in animals.
Controversy
Genetic modification in humans is a contested issue due to the variety of social and ethical issues it raises. One such controversy is the ability to modify the genes of future offspring to decrease the likelihood for certain diseases or modify the expression of chosen traits. In a recent case, an American teenager successfully sued a
sperm bank
A sperm bank, semen bank, or cryobank is a facility or enterprise which purchases, stores and sells human semen. The semen is produced and sold by men who are known as sperm donation, sperm donors. The sperm is purchased by or for other persons f ...
, because she had been born with
fragile X syndrome
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder. The average IQ in males with FXS is under 55, while affected females tend to be in the borderline to normal range, typically around 70–85. Physical features may include a lo ...
.
Some also cite the promotion of eugenics through certain applications of genetic modification, justifying the moratorium on research and funding in human trials in many countries.
[{{cite news, last1=Knapton, first1=Sarah, title=Robert Winston: my research could open door to 'risky' eugenics, url=https://www.telegraph.co.uk/news/science/science-news/10882336/Robert-Winston-my-research-could-open-door-to-risky-eugenics.html, access-date=11 April 2015, publisher=The Telegraph, date=June 2014]
References
Semen