Gadolinium(III) hydroxide is a chemical compound with the formula Gd(OH)₃. Its nanoparticles has a potential use for layering various drugs, such as

diclofenac Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It can be taken orally (swallowed by mouth), inserted rectally as a ...

ibuprofen Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. This includes dysmenorrhea, painful menstrual periods, migraines, and rheumatoid arthritis. It can be taken oral administration, ...

, and

naproxen Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, and inflammatory diseases such as rheumatoid arthritis, gout and fever. It is taken orally. It ...

Production and properties

Gadolinium(III) hydroxide can be produced in various ways such as the reaction of

gadolinium(III) nitrate Gadolinium(III) nitrate is an inorganic compound of gadolinium. This salt is used as a water-soluble neutron poison in nuclear reactors. Gadolinium nitrate, like all nitrate salts, is an oxidizing agent. The most common form of this substance is h ...

and

sodium hydroxide Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula . It is a white solid ionic compound consisting of sodium cations and hydroxide anions . Sodium hydroxide is a highly corrosive base (chemistry), ...

: :Gd(NO₃)₃ + NaOH → Gd(OH)₃ + NaNO₃ If this compound is heated to 307 °C, it decomposes to gadolinium(III) oxide-hydroxide(GdOOH), which in turn decomposes to

gadolinium(III) oxide Gadolinium(III) oxide (archaically gadolinia) is an inorganic compound with the formula Gd2O3. It is one of the most commonly available forms of the rare-earth element gadolinium, derivatives, of which are potential contrast agents for magnetic ...

if continually heated.

Uses

Gadolinium(III) hydroxide has no commercial uses. However, gadolinium(III) hydroxide nanoparticles have gained interest as a coating agent for various anti-inflammatory drugs such as diclofenac, ibuprofen, and naproxen due to their property to be non-

cytotoxic Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are toxic metals, toxic chemicals, microbe neurotoxins, radiation particles and even specific neurotransmitters when the system is out of balance. Also some types of dr ...

. The nanoparticles are produced by adding base anion exchange resin to gadolinium(III) nitrate.

References

{{Hydroxides Gadolinium compounds Hydroxides