Glutamate
MDA
MDA, mda or variants may refer to:
Businesses and organizations Political parties
* Meghalaya Democratic Alliance (2003–2008), in India
* Meghalaya Democratic Alliance (2018–present), in India
* Movement for Democracy in Africa, in Burkina F ...
receptor subunit 3A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''GRIN3A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene encodes a subunit of the N-methyl-D-aspartate (
NMDAR
The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the othe ...
) receptors, which belong to the superfamily of
glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the
knockout mouse
A knockout mouse, or knock-out mouse, is a genetically modified mouse (''Mus musculus'') in which researchers have inactivated, or " knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are importan ...
deficient in this subunit suggest that this gene may be involved in the development of
synaptic elements by modulating NMDA receptor activity.
See also
*
NMDA receptor
The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other ...
References
Further reading
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External links
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{{gene-9-stub
Ionotropic glutamate receptors