Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein (1009 aa) encoded by the ''GRID1'' gene. A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.

Function

This gene encodes a subunit of glutamate receptor

ligand-gated ion channel Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as sodium, Na+, potassium, K+, calcium, Ca2+, and/or chloride, Cl− to ...

. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system and is important in synaptic plasticity.

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the ''GRID1'' gene and increased risk of developing

schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...

Function

Clinical significance

See also

References

Further reading