Protein wntless homolog, commonly known as Wntless, is encoded in humans by the ''WLS''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. Wntless is a receptor for Wnt proteins in Wnt-secreting cells. Wntless was shown to be a cargo for the

retromer Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the ''trans''-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated pro ...

complex. It has been found essential for hair follicle induction. A

homozygous Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") () is the degree to which both copies of a chromosome or gene have the same genetic sequence. In other words, it is the degree of similarity of the alleles in an organism. Mos ...

missense mutation In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. It is a type of nonsynonymous substitution. Missense mutations change amino acids, which in turn alt ...

in the ''WLS'' gene was identified in Zaki syndrome.

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See also