HOME

TheInfoList



Click Here for Items Related To - GLRA1
OR:
GLRA1 on:   [Wikipedia]   [Google]   [Amazon]

Glycine receptor subunit alpha-1 is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''GLRA1''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Function

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed solely of alpha subunits. The GLRB gene encodes the alpha subunit of the receptor.


Clinical significance

Mutations in the gene have been associated with hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.


See also

* Glycine receptor * Stiff person syndrome * Hyperekplexia


References


Further reading

* * * * * * * * * * * * * * * * * *


External links

* Ion channels {{membrane-protein-stub