Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a
beta-glucosidase
β-Glucosidase (EC 3.2.1.21; systematic name β-D-glucoside glucohydrolase) is an enzyme that catalyses the following reaction:
: Hydrolysis of terminal, non-reducing β-D-glucosyl residues with release of β-D-glucose
Structure
β-Glucosidase ...
()
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
that in humans is encoded by the ''GBA3''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Cytosolic beta-glucosidase is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic
beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides.
GBA3 also has significant neutral
glycosylceramidase activity (), suggesting that it may be involved in a non-
lysosomal
A lysosome () is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane pr ...
catabolic pathway of
glucosylceramide metabolism.
See also
* Closely related enzymes
**
GBA: acid β-glucosidase,
**
GBA2: acid β-glucosidase (bile acid), also
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Cytosolic beta-glucosidase
EC 3.2.1
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