Growth arrest – specific 6, also known as GAS6, is a human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
coding for the GAS6 protein. It is similar to the
Protein S
Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In h ...
with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
Function
Gas6 is a
gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.
Interactions
Gas6 has been shown to
interact with
AXL receptor tyrosine kinase
Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the ''AXL'' gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. However, in the years since its discovery, researc ...
,
MerTK and
TYRO3.
The presence of Gla needs a
vitamin K
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-translational modification, post-synthesis modification of certain proteins ...
-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum. The action of vitamin K is essential on GAS6 function.
References
Further reading
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