Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA
B2) is a
G-protein coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large protein family, group of evoluti ...
subunit encoded by the GABBR2
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
in humans.
Function
B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.
upplied by OMIMref name="entrez" />
Interactions
GABBR2 has been shown to
interact with
GABBR1
Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the ''GABBR1'' gene.
Function
GABAB1 is a receptor for Gamma-Aminobutyric_acid, Gamma-aminobutyric acid. Upon binding, GABAB1 will produce a slo ...
.
See also
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GABAB receptor
GABAB receptors (GABABR) are G protein-coupled receptor, G-protein coupled receptors for gamma-aminobutyric acid (GABA), therefore making them metabotropic receptors, that are linked via G-proteins to potassium channels. The changing potassium ...
References
Further reading
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External links
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G protein-coupled receptors
{{transmembranereceptor-stub