Fu-Kuen Lin (; born 1941 in

Keelung Keelung ( ; zh, p=Jīlóng, c=基隆, poj=Ke-lâng), Chilung or Jilong ( ; ), officially known as Keelung City, is a major port city in northeastern Taiwan. The city is part of the Taipei–Keelung metropolitan area with neighboring New Ta ...

Taiwan Taiwan, officially the Republic of China (ROC), is a country in East Asia. The main geography of Taiwan, island of Taiwan, also known as ''Formosa'', lies between the East China Sea, East and South China Seas in the northwestern Pacific Ocea ...

) is a Taiwanese mycological physiologist, nephrologist and hematologist.

Education and career

Lin received his B.S. from

National Taiwan University National Taiwan University (NTU; zh, t=國立臺灣大學, poj=Kok-li̍p Tâi-oân Tāi-ha̍k, p=, s=) is a National university, national Public university, public research university in Taipei, Taiwan. Founded in 1928 during Taiwan under J ...

in 1964 and then a

M.S. A Master of Science (; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree. In contrast to the Master of Arts degree, the Master of Science degree is typically granted for studies in sciences, engineering and medicine ...

plant pathology Plant pathology or phytopathology is the scientific study of plant diseases caused by pathogens (infectious organisms) and environmental conditions (physiological factors). Plant pathology involves the study of pathogen identification, disease ...

in 1967. That year, he moved to the United States to study fungi physiology under Professor David Gottlieb at the

University of Illinois at Urbana-Champaign The University of Illinois Urbana-Champaign (UIUC, U of I, Illinois, or University of Illinois) is a public land-grant research university in the Champaign–Urbana metropolitan area, Illinois, United States. Established in 1867, it is the f ...

. Lin was awarded a doctorate in plant pathology in 1971. He held postdoctoral and visiting scientist positions at several institutions between 1971 and 1981. He was an associate research fellow at the Institute of Botany of

Academia Sinica Academia Sinica (AS, ; zh, t=中央研究院) is the national academy of the Taiwan, Republic of China. It is headquartered in Nangang District, Taipei, Nangang, Taipei. Founded in Nanjing, the academy supports research activities in mathemat ...

in Taiwan from 1975 to 1977 and was an adjunct associate professor at National Taiwan University from 1976 to 1977. Fu-Kuen Lin joined

Amgen Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical Corporation, company headquartered in Thousand Oaks, California. As one of the world's largest independent biotechnology companies, Amgen has a ...

, a biotech company as a research scientist in August 1981. He was involved with Amgen's recombinant human

erythropoietin Erythropoietin (; EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production ( erythropoiesis) in th ...

(EPO) project from the start, and was soon leading the team, which was developing EPO based on a small sample of the hormone that had been isolated by a team led by Eugene Goldwasser at the

University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...

. In 1983 his team successfully established the

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

coding for it and recombinant human erythropoietin was approved by the US

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

in June 1989 with the generic name epoetin alpha, tradename

Epogen Epoetin alfa, sold under the brand name Epogen among others, is a human erythropoietin produced in cell culture using recombinant DNA technology. Epoetin alfa is an erythropoiesis-stimulating agent. It stimulates erythropoiesis (increasing red ...

. Lin was also engaged in developing novel pharmaceutics and studying their molecular mechanisms. His primary research interests were in the fields of hematology, hypertension, immune regulation and fungi physiology. He retired from Amgen as the Director of the Department of Biomedical Sciences in 1998. Lin is the inventor of seven US patents covering “DNA Sequences Encoding Erythropoietin” and “Production of Erythropoietin”. Among other honors, he is a recipient of the “1989 Technology Corridor 100” Award; the 1990 “Quality of Life” Award; the “1995 Discoverers Award” (by Pharmaceutical Research and Manufacturers of America); and the Committee of 100, Pioneer Recognition Award in May 2002.

References

Selected works

* Lin F. (1984), ''DNA sequences encoding erythropoietin.'', US-Patent 4,703,008 (30 November 1984).
Lin F. et al. (1985) "Cloning and expression of the human erythropoietin gene" ''Proceedings of the National Academy of Sciences'' 82: 7580-7584.

References

''Fu-Kuen Lin’s Biography'' Monte Jade Science and Technology Association

Amgen 2004 Annual Report - Defining Moments - The Discovery of Epogen - The Story

''Fritsch v. Lin'' Board of Patent Appeals and Interferences, Patent and Trademark Office (P.T.O.) 3 December 1991
{{DEFAULTSORT:Lin, Fu Kuen 1941 births American microbiologists Amgen Living people National Taiwan University alumni Scientists from Keelung Taiwanese emigrants to the United States