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Fresenius SE & Co. KGaA is a German multinational
health care Health care, or healthcare, is the improvement or maintenance of health via the preventive healthcare, prevention, diagnosis, therapy, treatment, wikt:amelioration, amelioration or cure of disease, illness, injury, and other disability, physic ...
company based in
Bad Homburg vor der Höhe Bad Homburg vor der Höhe (, ) is the district town of the Hochtaunuskreis, Hesse, Germany, on the southern slope of the Taunus mountains. Bad Homburg is part of the Frankfurt Rhein-Main urban area. The town's official name is ''Bad Homburg ...
. It provides products and services for dialysis in hospitals, as well as inpatient and outpatient medical care. The company is involved in hospital management and in engineering and services for medical centers and other health care facilities. The company is ranked 411th in the ''Forbes'' Global 2000 list in 2023. In March 2022, it announced plans to merge with InterWell Health and Cricket Health to form a new company, which will operate under the InterWell Health brand, focused on services for the earlier stages of kidney disease.


Operations

There are four divisions: *
Fresenius Medical Care Fresenius Medical Care AG & Co. KGaA is an American-German healthcare company which provides kidney dialysis services through a network of 4,171 outpatient dialysis centers, serving 345,425 patients. The company primarily treats end-stage renal ...
, a publicly traded company of which Fresenius owns 30.8%, focuses on patients with chronic kidney failure. With its North American headquarters in
Waltham, Massachusetts Waltham ( ) is a city in Middlesex County, Massachusetts, United States, and was an early center for the labor movement as well as a major contributor to the Technological and industrial history of the United States, American Industrial Revoluti ...
, it holds a 38%
market share Market share is the percentage of the total revenue or sales in a Market (economics), market that a company's business makes up. For example, if there are 50,000 units sold per year in a given industry, a company whose sales were 5,000 of those ...
in the dialysis market in the United States. * Fresenius Helios is the largest hospital operator and provider of inpatient and outpatient in Germany. The Helios Kliniken has more than 110
hospitals A hospital is a healthcare institution providing patient treatment with specialized health science and auxiliary healthcare staff and medical equipment. The best-known type of hospital is the general hospital, which typically has an emergency ...
and more than 30,000 beds, treating over 4 million patients annually. * Fresenius Kabi is a supplier of essential drugs, clinical nutrition products, and
medical device A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assura ...
s. It produces generic versions of
intravenous Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutr ...
oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's Etymology, etymological origin is the Greek word ὄγ ...
products, such as
Paclitaxel Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered b ...
,
Irinotecan Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is ...
,
Oxaliplatin Oxaliplatin, sold under the brand name Eloxatin among others, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer. It is given by intravenous, infusion into a vein. Common side effects include paresth ...
, Gemcitabine,
Cytarabine Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. It is given b ...
,
Carboplatin Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It is a ...
,
Topotecan Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the ...
,
Docetaxel Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cel ...
, and Epirubicin. * Fresenius Vamed develops and manages health care facilities.


Structure

* Fresenius SE & Co. KGaA **
Fresenius Medical Care Fresenius Medical Care AG & Co. KGaA is an American-German healthcare company which provides kidney dialysis services through a network of 4,171 outpatient dialysis centers, serving 345,425 patients. The company primarily treats end-stage renal ...
*** NxStage Medical, Inc. ** Fresenius Helios *** Helios Kliniken GmbH **** Humaine Kliniken **** IDC Salud Holding S.L.U. ( Quirónsalud) **** Damp Group ** Fresenius Kabi AG *** Labesfal SA *** Fresenius Kabi Oncology Plc *** Dabur Pharma Ltd *** APP Pharmaceuticals, Inc *** Fenwal Holdings, Inc. ** Fresenius Vamed *
Calea UK Calea UK is a supplier of parenteral nutrition based in Runcorn, part of Fresenius Kabi. In July 2019 the Medicines and Healthcare products Regulatory Agency imposed restrictions on the company following an inspection which it said had revealed ...


History

The company was founded by Eduard Fresenius in 1912. Fresenius died in 1946. Else Kröner, his foster-daughter and protégée, who was still in pharmacy school at the time, inherited the company. Else Kröner rescued the company from significant debts by laying off the majority of staff and restructuring the business. Kröner died in 1988. Kröner's will left all of her assets to the Else Kröner-Fresenius-Foundation, which funds medical research. In 1966, the company began to sell dialysis machines. In 1982, the company converted to a
joint stock company A joint-stock company (JSC) is a business entity in which shares of the company's capital stock, stock can be bought and sold by shareholders. Each shareholder owns company stock in proportion, evidenced by their share (finance), shares (certifi ...
. In 1983, the company began producing polysulfone fiber membranes. In 1986, the company became a
public company A public company is a company whose ownership is organized via shares of share capital, stock which are intended to be freely traded on a stock exchange or in over-the-counter (finance), over-the-counter markets. A public (publicly traded) co ...
, listing shares on the
Frankfurt Stock Exchange The Frankfurt Stock Exchange (, former German name: , ''FWB'') is the world's 3rd oldest and 12th largest stock exchange by market capitalization. It has operations from 8:00 am to 10:00 pm ( German time). Organisation Located in Frankfurt, ...
. In 1996, the company merged its dialysis business into National Medical Care to form
Fresenius Medical Care Fresenius Medical Care AG & Co. KGaA is an American-German healthcare company which provides kidney dialysis services through a network of 4,171 outpatient dialysis centers, serving 345,425 patients. The company primarily treats end-stage renal ...
. In 1999, the company acquired the international nutrition business of
Pharmacia & Upjohn Pharmacia & Upjohn was a global pharmaceutical company formed by the merger of Sweden-based Pharmacia AB and the American company Upjohn in 1995. Today the remainder of the company is owned by Pfizer. In 1997, Pharmacia & Upjohn sold several b ...
and merged it with Fresenius Pharma to form Fresenius Kabi.https://www.fresenius.com/1294 In 2001, the company acquired Wittgensteiner Kliniken, a major operator of private hospitals in Germany. In 2005, the company acquired Helios. In March 2005, Fresenius Kabi AG acquired Labesfal (Laboratório de Especialidades Farmacêuticas Almiro S.A.). In September 2006, Helios Kliniken acquired a majority stake in Humaine Kliniken. HUMAINE operates six acute and post acute care hospitals in the fields of neurology, oncology and traumatology. On 16 July 2007 the company completed its conversion from an
Aktiengesellschaft (; abbreviated AG ) is a German language, German word for a corporation limited by Share (finance), share ownership (i.e., one which is owned by its shareholders) whose shares may be traded on a stock market. The term is used in Germany, Austria ...
(AG - German
public In public relations and communication science, publics are groups of individual people, and the public (a.k.a. the general public) is the totality of such groupings. This is a different concept to the sociology, sociological concept of the ''Öf ...
limited company) to a
Societas Europaea A (, ; "European society" or "company"; plural: ; abbr. SE) is a public company registered in accordance with the European corporate law, corporate law of the European Union (EU), introduced in 2004 with the Council Regulation on the Statute ...
, the
European Union The European Union (EU) is a supranational union, supranational political union, political and economic union of Member state of the European Union, member states that are Geography of the European Union, located primarily in Europe. The u ...
-wide equivalent. The company changed its legal status once again on 28 January 2011, becoming a
Kommanditgesellschaft auf Aktien A (abbreviated KG, ; from + ) is the German name for a limited partnership Types of business entity, business entity and is used in Germany, German, Belgium, Belgian, Netherlands, Dutch, Austrian, and some other European Union, European law, le ...
(KGaA - German partnership limited by shares) with a ''
Societas Europaea A (, ; "European society" or "company"; plural: ; abbr. SE) is a public company registered in accordance with the European corporate law, corporate law of the European Union (EU), introduced in 2004 with the Council Regulation on the Statute ...
'' as a partner with unlimited liability (SE & Co. KGaA). In August 2008, Fresenius Kabi acquired 73.3% of Dabur Pharma of India. In September 2008, Fresenius Kabi acquired APP Pharmaceuticals, Inc. In October 2011, the company agreed to acquire 51% of the share capital in Katholisches Klinikum Duisburg hospital. Also in October 2011, Helios Kliniken acquired 94.7% of the share capital in Damp Group. In September 2013, Fresenius acquired 41 hospitals from Rhön-Klinikum for €3.07 billion. In 2014, Fresenius sold its 5% stake in Rhön-Klinikum. In November 2014, the company announced that its Russian partners,
Sistema AFK Sistema PAO is a large Russian conglomerate company, founded by Vladimir Yevtushenkov, who was chairman of the corporation's board of directors until 2022. In April, Yevtushenkov's shareholding in Sistema has decreased to 49.2%, and he also ...
and Zenitco Finance Management, agreed to terminate their joint venture agreement that had been established in April 2014. The termination was prompted by changing political and regulatory circumstances in the region. In January 2016, Fresenius Kabi announced that it would acquire Becton Dickinson's prescription drug business. In February 2016, Fresenius Helios acquired the municipal hospital in
Velbert Velbert (, Low Rhenish: ''Vèlbed'') is a town in the district of Mettmann (district), Mettmann, in the German state of North Rhine-Westphalia. The town is renowned worldwide for the production of locks and fittings. Geography Velbert is located ...
, North Rhine-Westphalia. In January 2017, Fresenius acquired the largest Spanish hospital group, the Grupo Hospitalario Quirónsalud for €5.76 billion and merged it into the Helios Group, establishing the biggest hospital group of Europe. In September 2017, Fresenius Kabi acquired
Merck KGaA The Merck Group, branded and commonly known as Merck, is a German Multinational corporation, multinational science and technology company headquartered in Darmstadt, with about 60,000 employees and a presence in 66 countries. The group include ...
's
biosimilar A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product that is almost an identical copy of an original product that is manufactured by a different company. Biosimilars are officially approved ...
s business. In February 2019,
Fresenius Medical Care Fresenius Medical Care AG & Co. KGaA is an American-German healthcare company which provides kidney dialysis services through a network of 4,171 outpatient dialysis centers, serving 345,425 patients. The company primarily treats end-stage renal ...
acquired NxStage, a US-based maker of in-home dialysis devices, for $2 billion. Fresenius Kabi is a supplier of 0.9%
sodium chloride Sodium chloride , commonly known as Salt#Edible salt, edible salt, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. It is transparent or translucent, brittle, hygroscopic, and occurs a ...
Injection USP diluent for use with the
Pfizer–BioNTech COVID-19 vaccine The Pfizer–BioNTech COVID-19 vaccine, sold under the brand name Comirnaty, is an MRNA vaccine, mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with the America ...
.


Controversies


Concerns of use of hydroxyethyl starch and threats against researcher

In 2012, a paper was published raising concerns regarding the use of hydroxyethyl starch in
sepsis Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and s ...
. Fresenius Kabi, which makes the product, threatened legal action against the main author, Danish scientist Anders Perner.


Supply of faulty insulin syringes

In 2015, Fresenius Kabi Group pleaded guilty to breaches of United Kingdom's
Medicines Act 1968 The Medicines Act 1968 (c. 67) is an act of Parliament of the United Kingdom. Its official long title is "An Act to make new provision with respect to medicinal products and related matters, and for purposes connected therewith." It governs the ...
and was fined £500,000 by the Sheffield Crown Court for supplying faulty
insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...
syringes containing no insulin, leading to the death of Neil Judge from
diabetic ketoacidosis Diabetic ketoacidosis (DKA) is a potentially life-threatening acute complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion and occasionally ...
in 2010.


Bribery allegations

In 2019, the company paid $231 million to the
United States Department of Justice The United States Department of Justice (DOJ), also known as the Justice Department, is a United States federal executive departments, federal executive department of the U.S. government that oversees the domestic enforcement of Law of the Unite ...
to settle allegations of civil
bribery Bribery is the corrupt solicitation, payment, or Offer and acceptance, acceptance of a private favor (a bribe) in exchange for official action. The purpose of a bribe is to influence the actions of the recipient, a person in charge of an official ...
to obtain business in
Angola Angola, officially the Republic of Angola, is a country on the west-Central Africa, central coast of Southern Africa. It is the second-largest Portuguese-speaking world, Portuguese-speaking (Lusophone) country in both total area and List of c ...
,
Saudi Arabia Saudi Arabia, officially the Kingdom of Saudi Arabia (KSA), is a country in West Asia. Located in the centre of the Middle East, it covers the bulk of the Arabian Peninsula and has a land area of about , making it the List of Asian countries ...
,
Morocco Morocco, officially the Kingdom of Morocco, is a country in the Maghreb region of North Africa. It has coastlines on the Mediterranean Sea to the north and the Atlantic Ocean to the west, and has land borders with Algeria to Algeria–Morocc ...
, and
Spain Spain, or the Kingdom of Spain, is a country in Southern Europe, Southern and Western Europe with territories in North Africa. Featuring the Punta de Tarifa, southernmost point of continental Europe, it is the largest country in Southern Eur ...
. In January 2020, the ''
Süddeutsche Zeitung The ''Süddeutsche Zeitung'' (; ), published in Munich, Bavaria, is one of the largest and most influential daily newspapers in Germany. The tone of ''SZ'' is mainly described as centre-left, liberal, social-liberal, progressive-liberal, and ...
'' reported on tricks used by the health care group Fresenius, according to a case study by the Steuerjustigkeit network. The study shows that it is by no means just US digital groups that are shifting their profits to low-tax countries and that Fresenius is trying to reduce the tax burden by legal means with the help of branches in so-called tax havens and subsidiaries. Tax avoidance is not a prohibited tax evasion.


2022 Russian invasion in Ukraine

In response to the
2022 Russian invasion of Ukraine On 24 February 2022, , starting the largest and deadliest war in Europe since World War II, in a major escalation of the Russo-Ukrainian War, conflict between the two countries which began in 2014. The fighting has caused hundreds of thou ...
, Fresenius Medical Care continued its operations in Russia. Despite global calls for businesses to cease operations in Russia, the company has not made any official statements regarding changes to its business activities in the country.


References


Further reading

* Kamp, Michael / Neumann, Florian: Fresenius – 100 Years. Munich: August Dreesbach Verlag, 2012. .


External links

* {{DEFAULTSORT:Fresenius (company) Companies listed on the Frankfurt Stock Exchange Companies in the DAX index Companies in the S&P Europe 350 Dividend Aristocrats 1912 establishments in Germany Companies based in Hesse German brands Life sciences industry Medical and health organisations based in Hesse Medical technology companies of Germany Multinational companies headquartered in Germany Pharmaceutical companies of Germany Pharmaceutical companies established in 1912 Bad Homburg vor der Höhe Societas Europaea companies