Frank Fenner
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Frank John Fenner (21 December 1914 – 22 November 2010) was an Australian scientist with a distinguished career in the field of
virology Virology is the Scientific method, scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host (biology), ...
. His two greatest achievements are cited as overseeing the eradication of
smallpox Smallpox was an infectious disease caused by Variola virus (often called Smallpox virus), which belongs to the genus '' Orthopoxvirus''. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (W ...
, and the attempted control of Australia's rabbit plague through the introduction of ''
Myxoma virus Myxoma virus is a poxvirus in the genus '' Leporipoxvirus''. The two broad geographic types of Myxoma virus are Californian and South American. Californian myxoma virus is found on the West Coast of the United States, the Baja Peninsula of Mexi ...
''. The
Australian Academy of Science The Australian Academy of Science was founded in 1954 by a group of distinguished Australians, including Australian Fellows of the Royal Society of London. The first president was Sir Mark Oliphant. The academy is modelled after the Royal Soci ...
awards annually the prestigious Fenner Medal for distinguished research in biology by a scientist under 40 years of age.


Early life and education

Frank Johannes Fenner was born in
Ballarat Ballarat ( ) () is a city in the Central Highlands of Victoria, Australia. At the 2021 census, Ballarat had a population of 111,973, making it the third-largest urban inland city in Australia and the third-largest city in Victoria. Within mo ...
in 1914. The family moved to
Adelaide Adelaide ( , ; ) is the list of Australian capital cities, capital and most populous city of South Australia, as well as the list of cities in Australia by population, fifth-most populous city in Australia. The name "Adelaide" may refer to ei ...
,
South Australia South Australia (commonly abbreviated as SA) is a States and territories of Australia, state in the southern central part of Australia. With a total land area of , it is the fourth-largest of Australia's states and territories by area, which in ...
in November 1916. He attended Rose Park Primary School and
Thebarton Thebarton ( ), formerly Theberton, on Kaurna land, is an inner-western suburb of Adelaide, South Australia in the City of West Torrens. The suburb is bounded by the River Torrens to the north, Port Road and Bonython Park to the east, Kintore St ...
Technical School. He attended the
University of Adelaide The University of Adelaide is a public university, public research university based in Adelaide, South Australia. Established in 1874, it is the third-oldest university in Australia. Its main campus in the Adelaide city centre includes many Sa ...
, where he earned degrees in medicine and surgery in 1938. That year, uneasy about Hitler's rise, he legally changed his middle name from Johannes (the first name of his German-born paternal grandfather) to John.


Career

In May 1937, Fenner was a member of an Adelaide University anthropological expedition to Nepabunna Mission in the northern
Flinders Ranges The Flinders Ranges are the largest mountain ranges in South Australia, which starts about north of Adelaide. The ranges stretch for over from Port Pirie to Lake Callabonna. The Adnyamathanha people are the Aboriginal group who have inhab ...
in
South Australia South Australia (commonly abbreviated as SA) is a States and territories of Australia, state in the southern central part of Australia. With a total land area of , it is the fourth-largest of Australia's states and territories by area, which in ...
led by J. B. Cleland, which also included Charles P. Mountford as
ethnologist Ethnology (from the , meaning 'nation') is an academic field and discipline that compares and analyzes the characteristics of different peoples and the relationships between them (compare cultural, social, or sociocultural anthropology). Scien ...
and photographer, as well as botanist
Thomas Harvey Johnston Thomas Harvey Johnston (9 December 1881 – 30 August 1951) was an Australian biologist and parasitologist. He championed the efforts to eradicate the invasive Opuntia, prickly pear. Life and times Johnston was born in 1881 at Balmain, Sydney, ...
and others. From 1940 to 1946 he was a captain and Major in the
Australian Army Medical Corps The Royal Australian Army Medical Corps (RAAMC) is the branch of the Australian Army responsible for providing medical care to Army personnel. The AAMC was formed in 1902 through the amalgamation of medical units of the various Australian colon ...
with service in Australia,
Palestine Palestine, officially the State of Palestine, is a country in West Asia. Recognized by International recognition of Palestine, 147 of the UN's 193 member states, it encompasses the Israeli-occupied West Bank, including East Jerusalem, and th ...
,
Egypt Egypt ( , ), officially the Arab Republic of Egypt, is a country spanning the Northeast Africa, northeast corner of Africa and Western Asia, southwest corner of Asia via the Sinai Peninsula. It is bordered by the Mediterranean Sea to northe ...
,
New Guinea New Guinea (; Hiri Motu: ''Niu Gini''; , fossilized , also known as Papua or historically ) is the List of islands by area, world's second-largest island, with an area of . Located in Melanesia in the southwestern Pacific Ocean, the island is ...
and
Borneo Borneo () is the List of islands by area, third-largest island in the world, with an area of , and population of 23,053,723 (2020 national censuses). Situated at the geographic centre of Maritime Southeast Asia, it is one of the Greater Sunda ...
, as medical officer in field ambulance and Casualty Clearing Station,
pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...
to general hospital and malariologist. For his work in combating
malaria Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomitin ...
in Papua New Guinea he was made a Member of the
Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding valuable service in a wide range of useful activities. It comprises five classes of awards across both civil and military divisions, the most senior two o ...
in 1945.It's an Honour: MBE
/ref>Citation record of MBE
/ref> Following his war-time service he was recruited by
Frank Macfarlane Burnet Sir Frank Macfarlane Burnet (3 September 1899 – 31 August 1985), usually known as Macfarlane or Mac Burnet, was an Australian virology, virologist known for his contributions to immunology. He won a Nobel Prize in Physiology or Medicine, Nobe ...
to work at the
Walter and Eliza Hall Institute of Medical Research Walter may refer to: People and fictional characters * Walter (name), including a list of people and fictional and mythical characters with the given name or surname * Little Walter, American blues harmonica player Marion Walter Jacobs (1930–1 ...
in Melbourne. Initially they worked on
smallpox Smallpox was an infectious disease caused by Variola virus (often called Smallpox virus), which belongs to the genus '' Orthopoxvirus''. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (W ...
in mice, for which he coined the term "
mousepox Ectromelia virus (ECTV) is a virus of the family ''Poxviridae'' and the genus ''Orthopoxvirus'' that causes mousepox, a disease of mice. It has only been seen in mouse colonies kept for research purposes but believed that wild populations of mi ...
", and later on the
genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...
of
poxvirus ''Poxviridae'' is a family of double-stranded DNA viruses. Vertebrates and arthropods serve as natural hosts. The family contains 22 genera that are assigned to two subfamilies: ''Chordopoxvirinae'' and ''Entomopoxvirinae''. ''Entomopoxvirinae'' ...
. In 1949, he received a fellowship to study at the
Rockefeller Institute for Medical Research The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified ...
in New York City, he worked on
mycobacterium ''Mycobacterium'' is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (''Mycobacterium tuberculo ...
Bairnsdale bacillus, which causes
Buruli ulcer Buruli ulcer () is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, with most cases occurring in Sub-Saharan Africa and Australia. The first sign of infection i ...
, the third most important mycobacterial disease worldwide after
tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...
and
leprosy Leprosy, also known as Hansen's disease (HD), is a Chronic condition, long-term infection by the bacteria ''Mycobacterium leprae'' or ''Mycobacterium lepromatosis''. Infection can lead to damage of the Peripheral nervous system, nerves, respir ...
. Here he worked with and was influenced by René Dubos, who is one of the claimed originators of the phrase "
Think Globally, Act Locally "Think globally, act locally" or "Think global, act local" is a phrase that has been used in various contexts, including planning, environment, community empowerment, education, mathematics, business and the church. Definition "Think globally, ac ...
".


In Canberra, 1949–2010

Returning to Australia in 1949, he was appointed professor of
microbiology Microbiology () is the branches of science, scientific study of microorganisms, those being of unicellular organism, unicellular (single-celled), multicellular organism, multicellular (consisting of complex cells), or non-cellular life, acellula ...
at the new
John Curtin School of Medical Research The John Curtin School of Medical Research (JCSMR) is an Australian multidisciplinary translational medical research institute and postgraduate education centre that forms part of the Australian National University (ANU) in Canberra. The school ...
at the
Australian National University The Australian National University (ANU) is a public university, public research university and member of the Group of Eight (Australian universities), Group of Eight, located in Canberra, the capital of Australia. Its main campus in Acton, A ...
,
Canberra Canberra ( ; ) is the capital city of Australia. Founded following the Federation of Australia, federation of the colonies of Australia as the seat of government for the new nation, it is Australia's list of cities in Australia, largest in ...
. Here he began studying viruses again, in particular the
myxoma virus Myxoma virus is a poxvirus in the genus '' Leporipoxvirus''. The two broad geographic types of Myxoma virus are Californian and South American. Californian myxoma virus is found on the West Coast of the United States, the Baja Peninsula of Mexi ...
. Throughout the 1940s and 1950s Australia had severe rabbit plagues. Fenner's work on the myxoma virus showed that initially it killed rabbits in 9 to 11 days and was 99.5% lethal. Under heavy selection pressure, the few rabbits that survived developed resistance, which meant that the pest was never completely eradicated, but their numbers were reduced. Prior to the release of the virus as a
biological control Biological control or biocontrol is a method of controlling pests, whether pest animals such as insects and mites, weeds, or pathogens affecting animals or plants by using other organisms. It relies on predation, parasitism, herbivory, or o ...
for the rabbits, Fenner,
Frank Macfarlane Burnet Sir Frank Macfarlane Burnet (3 September 1899 – 31 August 1985), usually known as Macfarlane or Mac Burnet, was an Australian virology, virologist known for his contributions to immunology. He won a Nobel Prize in Physiology or Medicine, Nobe ...
and
Ian Clunies Ross Sir William Ian Clunies Ross (22 February 189920 June 1959) was an Australian veterinary scientist. He has been described as the "architect" of Australia's scientific boom, for his stewardship of the Commonwealth Scientific and Industrial Re ...
famously injected themselves with myxoma virus, to prove it was not dangerous for humans. From 1967 to 1973 Fenner was Director of the John Curtin School of Medical Research. In 1977, he was named the chairman of the Global Commission for the Certification of Smallpox Eradication, the same year the last known case of naturally transmitted smallpox occurred in
Somalia Somalia, officially the Federal Republic of Somalia, is the easternmost country in continental Africa. The country is located in the Horn of Africa and is bordered by Ethiopia to the west, Djibouti to the northwest, Kenya to the southwest, th ...
. Fenner announced the
eradication of smallpox Smallpox was an infectious disease caused by Variola virus (often called Smallpox virus), which belongs to the genus '' Orthopoxvirus''. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WH ...
to the World Health Assembly on 8 May 1980. This success story is regarded as the greatest achievement of the
World Health Organization The World Health Organization (WHO) is a list of specialized agencies of the United Nations, specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Gen ...
. Before its eradication, smallpox was one of the world's most virulent viruses, responsible for millions of deaths, and leaving many of the victims who survived with disfiguring scars for life. Fenner had an abiding interest in the environment, and was the foundation Director of the Centre for Resources and Environmental Studies at the ANU (1973), where he worked until his retirement in 1979, and which became part of the Fenner School of Environment and Society in 2007. He was a keen supporter of Australia having an ecologically, socially sustainable population. He was emeritus professor at the John Curtin School of Medical Research. In June 2010, he predicted in an interview with ''
The Australian ''The Australian'', with its Saturday edition ''The Weekend Australian'', is a broadsheet daily newspaper published by News Corp Australia since 14 July 1964. As the only Australian daily newspaper distributed nationally, its readership of b ...
'' the extinction of the human race within a century, primarily as the result of
human overpopulation Human overpopulation (or human population overshoot) is the idea that human populations may become too large to be sustainability, sustained by their environment or resources in the long term. The topic is usually discussed in the context of wor ...
,
environmental degradation Environment most often refers to: __NOTOC__ * Natural environment, referring respectively to all living and non-living things occurring naturally and the physical and biological factors along with their chemical interactions that affect an organism ...
and
climate change Present-day climate change includes both global warming—the ongoing increase in Global surface temperature, global average temperature—and its wider effects on Earth's climate system. Climate variability and change, Climate change in ...
. He died in Canberra on the morning of 22 November 2010 after a brief illness, and days after the birth of his first great-grandchild.


Personal life

In 1944 Fenner met Bobbie Roberts. Ellen Margaret 'Bobbie' Roberts was a trained midwife and nurse. During World War II she worked on
malaria Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomitin ...
with the Australian Army Nursing Service and through her work met Fenner. Shortly after they met they married in a Catholic ceremony (despite Fenner being an atheist). While keen to have children, the couple were infertile and with Bobbie having a hysterectomy in 1949 they decided to adopt. They subsequently adopted two children. Marilyn Aldus Fenner was born on 27 June 1950. Her biological parents were unknown. Victoria Fenner (born 1 March 1943) was adopted later at the request of her father (Fenner's younger brother Tom) after the death in a fire of Victoria's mother (Beverley Slaney). On 30 March 1958, Victoria Fenner shot and killed herself, as part of a supposed suicide pact with another child, Catherine Webb, who provided the rifle and bullets. The coronial inquiry heard she had been passing through a period of extreme mental and spiritual disturbance and the coroner declared her death a suicide. Fenner himself was unable to fathom a motive, other than she was upset from reading
Neville Shute Nevil Shute Norway (17 January 189912 January 1960) was an English novelist and aeronautical engineer who spent his later years in Australia. He used his full name in his engineering career and Nevil Shute as his pen name to protect his engine ...
's book, '' On the Beach''. Bobbie Fenner was diagnosed with cancer in 1989 and eventually died in 1994. Marilyn Fenner and her family then moved into the family home and looked after her father until his death.


Publications

* Frank Fenner and
Francis Ratcliffe Francis Noble Ratcliffe OBE (11 January 1904 – 8 December 1970) was an Australian zoologist and conservationist. Ratcliffe was born a British citizen in Calcutta, India. He was educated at Berkhamsted School and the University of Oxford in ...
, ''Myxmatosis''. Cambridge University Press, 1965. *


Honours

Of the many honours Fenner received throughout his career, there are the following: * Member of the
Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding valuable service in a wide range of useful activities. It comprises five classes of awards across both civil and military divisions, the most senior two o ...
(MBE), 19 July 1945 * Companion of the
Order of St Michael and St George The Most Distinguished Order of Saint Michael and Saint George is a British order of chivalry founded on 28 April 1818 by George, Prince of Wales (the future King George IV), while he was acting as prince regent for his father, King George III ...
(CMG) 12 June 1976, in recognition of service to medical research * The
Macfarlane Burnet Medal and Lecture The Macfarlane Burnet Medal and Lecture is a biennial award given by the Australian Academy of Science to recognise outstanding scientific research in the biological sciences. It was established in 1971 and honours the memory of the Nobel laureat ...
of the
Australian Academy of Science The Australian Academy of Science was founded in 1954 by a group of distinguished Australians, including Australian Fellows of the Royal Society of London. The first president was Sir Mark Oliphant. The academy is modelled after the Royal Soci ...
, 1985 * The
Japan Prize is awarded to individuals whose original and outstanding achievements in science and technology are recognized as having advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind. As of 2024, the Japan Prize h ...
(Preventive Medicine), 1988 (with
Donald Henderson Donald Ainslie Henderson (September 7, 1928 – August 19, 2016) was an American physician, educator, and epidemiologist who directed a 10-year international effort (1967–1977) that eradicated smallpox throughout the world and launched int ...
and Isao Arita) * Companion of the
Order of Australia The Order of Australia is an Australian honours and awards system, Australian honour that recognises Australian citizens and other persons for outstanding achievement and service. It was established on 14 February 1975 by Elizabeth II, Monarch ...
(AC) 26 January 1989, in recognition of service to medical science, to public health and to the environment *
Copley medal The Copley Medal is the most prestigious award of the Royal Society of the United Kingdom, conferred "for sustained, outstanding achievements in any field of science". The award alternates between the physical sciences or mathematics and the bio ...
of the
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
, 1995 *
Albert Einstein World Award of Science The Albert Einstein World Award for Science is an annual award given by the World Cultural Council "as a means of recognition and encouragement for scientific and technological research and development", with special consideration for researche ...
, 2000 * Clunies Ross Lifetime Contribution National Science and Technology Award, 2002 * Both the Frank Fenner building which houses the ANU Medical School and Faculty of Science, and a residential college Fenner Hall are named in honour of Frank Fenner. *
WHO The World Health Organization (WHO) is a specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Geneva, Switzerland, and has 6 regional offices and 15 ...
Medal *
Mueller Medal The Australian and New Zealand Association for the Advancement of Science (ANZAAS) is an organisation that was founded in 1888 as the Australasian Association for the Advancement of Science to promote science. It was modelled on the British ...
(1964) and
ANZAAS Medal The Australian and New Zealand Association for the Advancement of Science (ANZAAS) is an organisation that was founded in 1888 as the Australasian Association for the Advancement of Science to promote science. It was modelled on the British ...
(1980) * ANZAC Peace Prize *
Matthew Flinders Medal and Lecture The Matthew Flinders Medal and Lecture of the Australian Academy of Science is awarded biennially to recognise exceptional research by Australian scientists in the physical sciences. Nominations can only be made by Academy Fellows. Recipients Sour ...
, 1967 * Britannica Australia Award for Medicine * 2002 Prime Minister's Prize for Science * ACT Senior Australian of the Year 2005 * The federal Division of Fraser, named for Jim Fraser, was renamed after Frank Fenner for the 2016 general election. This was due to the AEC's plans to name a seat in Victoria in honour of deceased Prime Minister
Malcolm Fraser John Malcolm Fraser (; 21 May 1930 – 20 March 2015) was an Australian politician who served as the 22nd prime minister of Australia from 1975 to 1983. He held office as the leader of the Liberal Party of Australia, and is the fourth List of ...
.


References


External links


Online Guide to Records at the South Australian Museum Archives


* ttps://web.archive.org/web/20110228170525/http://jcsmr.anu.edu.au/about/fenner/index.php EmerProfessor Frank Fenner's Webpage at JCMSR
Australian War Memorial Honours and Awards Database
* Originally published in ''Historical Records of Australian Science'', vol.24, no.1, pp. 109–133, 2013. {{DEFAULTSORT:Fenner, Frank 1914 births 2010 deaths Albert Einstein World Award of Science Laureates Australian virologists Australian microbiologists Smallpox eradication Fellows of the Australian Academy of Science Australian atheists Fellows of the Royal Society Foreign associates of the National Academy of Sciences Companions of the Order of Australia Australian Companions of the Order of St Michael and St George Australian Members of the Order of the British Empire Recipients of the Copley Medal People from Ballarat WEHI alumni Military personnel from Victoria (state) Royal Australian Army Medical Corps officers Australian Army personnel of World War II