Frank's sign is a diagonal crease in the ear lobe extending from the tragus across the

lobule In anatomy, a lobe is a clear anatomical division or extension of an organ (as seen for example in the brain, lung, liver, or kidney) that can be determined without the use of a microscope at the gross anatomy level. This is in contrast to t ...

to the rear edge of the auricle. The sign is named after

Sanders T. Frank Dr. Sanders T. Frank M.D. (May 11, 1938 – September 14, 1997) was an American pulmonologist known for describing Frank's sign. He was born in Middletown, Connecticut Middletown is a city located in Middlesex County, Connecticut, United S ...

. It has been hypothesised that Frank's sign is indicative of

cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, ...

and/or

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level (hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...

. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease in diabetics. There have also been reported cases of Frank's sign being a predictor of cerebral infarctions. A link between Frank's sign and

premature aging Progeroid syndromes (PS) are a group of rare genetic disorders that mimic physiological aging, making affected individuals appear to be older than they are. The term ''progeroid syndrome'' does not necessarily imply progeria ( Hutchinson–Gilfo ...

and the loss of

dermal The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided in ...

and

vascular Blood vessels are the structures of the circulatory system that transport blood throughout the human body. These vessels transport blood cells, nutrients, and oxygen to the tissues of the body. They also take waste and carbon dioxide away from ...

fiber Fiber or fibre (from la, fibra, links=no) is a natural or artificial substance that is significantly longer than it is wide. Fibers are often used in the manufacture of other materials. The strongest engineering materials often incorpora ...

s has also been hypothesized. Some studies have focused on association between bilateral earlobe crease and

coronary artery disease Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves Ischemia, the reduction of blood flow to the myocardium, heart muscle due to build-up o ...

. It is probably prudent to consider Frank's Sign alongside other clinical markers of physiological

ageing Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In ...

, rather than utilising it as a stand-alone sign in the identification of coronary artery disease.

Severity

*Grade 3 – A deep crease across the whole of the earlobe. *Grade 2b – Creased more than halfway across the earlobe. *Grade 2a – A superficial crease across the earlobe. *Grade 1 – A small amount of wrinkling on the earlobe.

Notable individuals with Franks' sign

* Dick Van Dyke *

George W. Bush George Walker Bush (born July 6, 1946) is an American politician who served as the 43rd president of the United States from 2001 to 2009. A member of the Republican Party, Bush family, and son of the 41st president George H. W. Bush, he ...

Mel Gibson Mel Columcille Gerard Gibson (born January 3, 1956) is an American actor, film director, and producer. He is best known for his action hero roles, particularly his breakout role as Max Rockatansky in the first three films of the post-apocal ...

Steven Spielberg Steven Allan Spielberg (; born December 18, 1946) is an American director, writer, and producer. A major figure of the New Hollywood era and pioneer of the modern blockbuster, he is the most commercially successful director of all time. Spi ...

References

External links

Further image of Frank's Sign
{{Cardiovascular system symptoms and signs Medical signs