Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

that catalyzes the following reactions: * conversion of

formiminoglutamate Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitami ...

and

tetrahydrofolate Tetrahydrofolic acid (THFA), or tetrahydrofolate, is a folic acid derivative. Metabolism In humans, tetrahydrofolic acid is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by methotrexate. It is convert ...

into

formiminotetrahydrofolate 5-Formiminotetrahydrofolate is an intermediate in the catabolism of histidine Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an Amine, α-amino group (which is in the protonated � ...

and

glutamate Glutamic acid (symbol Glu or E; known as glutamate in its anionic form) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a Essential amino acid, non-essential nutrient for humans, meaning that ...

(

glutamate formimidoyltransferase Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions: * 5-formimidoyltetrahydrofolate + L-glutamate tetrahydrofolate + N-formimidoyl-L-glutamate ...

activity, ) * subsequent deamination of

to 5,10-methenyltetrahydrofolate and

ammonia Ammonia is an inorganic chemical compound of nitrogen and hydrogen with the chemical formula, formula . A Binary compounds of hydrogen, stable binary hydride and the simplest pnictogen hydride, ammonia is a colourless gas with a distinctive pu ...

(

formimidoyltetrahydrofolate cyclodeaminase In enzymology, a formimidoyltetrahydrofolate cyclodeaminase () is an enzyme that catalyzes the chemical reaction :5-formimidoyltetrahydrofolate \rightleftharpoons 5,10-methenyltetrahydrofolate + NH3 Hence, this enzyme has one substrate, 5-formim ...

activity, ) Its name comes from the two activities it catalyzes.

Role in pathology

Mutations of the FTCD gene cause

glutamate formiminotransferase deficiency Glutamic acid (symbol Glu or E; known as glutamate in its anionic form) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can s ...

References

{{Amino acid metabolism enzymes

Role in pathology

See also

References