Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics m ...

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhal ...

, used for the treatment of

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wi ...

. It is administered intramuscularly. It was discovered at

Janssen Pharmaceutica Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based America ...

in 1963.C. Janssen, NV Res. Lab., (1963) A 2007

systematic review A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on t ...

investigated the efficacy of fluspirilene decanoate for people with schizophrenia:

Synthesis

*Sidechain precursor

312-04-7 31 may refer to: * 31 (number) Years * 31 BC * AD 31 * 1931 CE ('31) * 2031 CE ('31) Music * ''Thirty One'' (Jana Kramer album), 2015 * ''Thirty One'' (Jarryd James album), 2015 * "Thirty One", a song by Karma to Burn from the album '' Wil ...

(1) also used for:

penfluridol Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and flu ...

, clopimozide, amperozide,

pimozide Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis ...

, lidoflazine. *Piperidine 021-25-6also used for Spiroxantrine,

Spiperone Spiperone (Spiroperidol; brand name: Spiropitan ( JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spip ...

, Ro65-6570, RP-23618, Spirilene,

Spiramide Spiramide (developmental code name AMI-193) is an experimental antipsychotic that acts as a binding selectivity, selective 5-HT2A, 5-HT2A, 5-HT1A, 5-HT1A, and D2 receptor, D2 receptor (biochemistry), receptor receptor antagonist, antagonist. It h ...

R 5260

109-69-9 1 (one, unit, unity) is a number representing a single or the only entity. 1 is also a numerical digit and represents a single unit of counting or measurement. For example, a line segment of ''unit length'' is a line segment of length 1. I ...

etc.

1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene)

(1) & 1-Phenyl-1,3,8-Triazaspiro .5ecan-4-One 021-25-6(2) give ' (3).

References

Belgian inventions 1-(4,4-Bis(4-fluorophenyl)butyl)piperidines Janssen Pharmaceutica Typical antipsychotics Spiro compounds Anilines {{nervous-system-drug-stub

Synthesis

See also

References