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Phlegm (; , ''phlégma'', "inflammation", "
humour Humour (English in the Commonwealth of Nations, Commonwealth English) or humor (American English) is the tendency of experiences to provoke laughter and provide amusement. The term derives from the humorism, humoral medicine of the ancient Gre ...
caused by heat") is
mucus Mucus (, ) is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both Serous fluid, serous and muc ...
produced by the
respiratory system The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies grea ...
, excluding that produced by the throat
nasal Nasal is an adjective referring to the nose, part of human or animal anatomy. It may also be shorthand for the following uses in combination: * With reference to the human nose: ** Nasal administration, a method of pharmaceutical drug delivery * ...
passages. It often refers to respiratory mucus expelled by
cough A cough is a sudden expulsion of air through the large breathing passages which can help clear them of fluids, irritants, foreign particles and Microorganism, microbes. As a protective reflex, coughing can be repetitive with the cough reflex fol ...
ing, otherwise known as
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked-eye examination, microbiological investigation of respiratory infections, and Cytopathology, cytological ...
. Phlegm, and mucus as a whole, is in essence a water-based gel consisting of
glycoproteins Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known a ...
,
immunoglobulins An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that cause di ...
,
lipids Lipids are a broad group of organic compounds which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins Vitamin A, A, Vitamin D, D, Vitamin E, E and Vitamin K, K), monoglycerides, diglycerides, phospholipids, and others. The fu ...
and other substances. Its composition varies depending on
climate Climate is the long-term weather pattern in a region, typically averaged over 30 years. More rigorously, it is the mean and variability of meteorological variables over a time spanning from months to millions of years. Some of the meteoro ...
,
genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...
, and state of the
immune system The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to bacteria, as well as Tumor immunology, cancer cells, Parasitic worm, parasitic ...
. Its color can vary from transparent to pale or dark yellow and green, from light to dark brown, and even to dark grey depending on the contents. The body naturally produces about 1 quart (about 1 litre) of phlegm every day to capture and clear substances in the air and
bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...
from the
nose A nose is a sensory organ and respiratory structure in vertebrates. It consists of a nasal cavity inside the head, and an external nose on the face. The external nose houses the nostrils, or nares, a pair of tubes providing airflow through the ...
and
throat In vertebrate anatomy, the throat is the front part of the neck, internally positioned in front of the vertebrae. It contains the Human pharynx, pharynx and larynx. An important section of it is the epiglottis, separating the esophagus from the t ...
.


Distinction between mucus and phlegm

Contrary to popular misconception and misuse, mucus and phlegm are not always the same.


Mucus

Mucus is a normal protective layering around the airway, eye, nasal turbinate, and
urogenital tract The genitourinary system, or urogenital system, are the sex organs of the reproductive system and the organ (biology), organs of the urinary system. These are grouped together because of their proximity to each other, Development of the urinary a ...
. Mucus is an adhesive viscoelastic gel produced in the airway by
submucosal glands Submucosal glands can refer to various racemose exocrine glands of the mucous type. These glands secrete mucus to facilitate the movement of particles along the body's various tubes, such as the throat and intestines. The mucosa is the lining o ...
and
goblet cells Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. The goblet cells mainly use the merocrine method of secretion, secreting ...
and is principally water. It also contains high-molecular weight mucous
glycoproteins Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known a ...
that form linear polymers.


Phlegm

Phlegm is more related to disease than mucus, and can be troublesome for the individual to excrete from the body. Phlegm is a thick secretion in the airway during disease and inflammation. Phlegm usually contains mucus with virus, bacteria, other debris, and sloughed-off inflammatory cells. Once phlegm has been expectorated by a cough, it becomes
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked-eye examination, microbiological investigation of respiratory infections, and Cytopathology, cytological ...
.


Excessive phlegm creation

There are multiple factors that can contribute to an excess of phlegm in the throat or
larynx The larynx (), commonly called the voice box, is an organ (anatomy), organ in the top of the neck involved in breathing, producing sound and protecting the trachea against food aspiration. The opening of larynx into pharynx known as the laryngeal ...
. *Vocal abuse: Vocal abuse is the misuse or overuse of the voice in an unhealthy fashion such as clearing the throat, yelling, screaming, talking loudly, or singing incorrectly. ** Clearing the throat: Clearing the throat removes or loosens phlegm but the vocal cords hit together causing inflammation and therefore more phlegm. ** Yelling/screaming: Yelling and screaming both cause the vocal cords to hit against each other causing inflammation and phlegm. **
Nodules Nodule may refer to: *Nodule (geology), a small rock or mineral cluster *Manganese nodule, a metallic concretion found on the seafloor *Nodule (medicine), a small aggregation of cells *Root nodule Root nodules are found on the roots of plants, p ...
: Excessive yelling, screaming, and incorrect singing as well as other vocal abusive habits can cause
vocal fold nodule Vocal cord nodules are bilaterally symmetrical benign white masses ( nodules) that form at the midpoint of the vocal folds. Although diagnosis involves a physical examination of the head and neck, as well as perceptual voice measures, visualizat ...
s. *
Smoking Smoking is a practice in which a substance is combusted, and the resulting smoke is typically inhaled to be tasted and absorbed into the bloodstream of a person. Most commonly, the substance used is the dried leaves of the tobacco plant, whi ...
: Smoke is hot, dry, polluted air which dries out the vocal cords. With each breath in of smoke, the larynx is polluted with toxins that inhibit it from rehydrating for about 3 hours. The vocal cords need a fair amount of lubrication and swell from inflammation when they do not have enough of it. When the vocal folds swell and are inflamed, phlegm is often created to attempt to ease the dryness. *
Illness A disease is a particular abnormal condition that adversely affects the structure or function (biology), function of all or part of an organism and is not immediately due to any external injury. Diseases are often known to be medical condi ...
: During illness like the
flu Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These sympto ...
,
cold Cold is the presence of low temperature, especially in the atmosphere. In common usage, cold is often a subjectivity, subjective perception. A lower bound to temperature is absolute zero, defined as 0.00K on the Kelvin scale, an absolute t ...
, and
pneumonia Pneumonia is an Inflammation, inflammatory condition of the lung primarily affecting the small air sacs known as Pulmonary alveolus, alveoli. Symptoms typically include some combination of Cough#Classification, productive or dry cough, ches ...
, phlegm becomes more excessive as an attempt to get rid of the bacteria or viral particles within the body. A major illness associated with excess phlegm is
acute bronchitis Acute bronchitis, also known as a chest cold, is short-term bronchitis – inflammation of the bronchus, bronchi (large and medium-sized airways) of the lungs. The most common symptom is a cough. Other symptoms include sputum, coughing up mucus, ...
. A major symptom of acute bronchitis is an excess amount of phlegm and is usually caused by a viral infection, and only bacterial infections, which are rare, are to be treated with an antibiotic. *
Hay fever Allergic rhinitis, of which the seasonal type is called hay fever, is a type of rhinitis, inflammation in the nose that occurs when the immune system overreacts to allergens in the air. It is classified as a Allergy, type I hypersensitivity re ...
, asthma: In hay fever and asthma, the inner lining in the
bronchioles The bronchioles ( ) are the smaller branches of the bronchial airways in the lower respiratory tract. They include the terminal bronchioles, and finally the respiratory bronchioles that mark the start of the respiratory zone delivering air to t ...
becomes inflamed and creates an excess amount of phlegm that can clog up air pathways. *
Air pollution Air pollution is the presence of substances in the Atmosphere of Earth, air that are harmful to humans, other living beings or the environment. Pollutants can be Gas, gases like Ground-level ozone, ozone or nitrogen oxides or small particles li ...
: In studies of children, air pollutants have been found to increase phlegm by drying out and irritating parts of the throat.


Removing phlegm

Phlegm naturally drains down into the back of the throat and can be
swallowed Swallowing, also called deglutition or inglutition in scientific and medical contexts, is a physical process of an animal's digestive tract (e.g. that of a human body) that allows for an ingested substance (typically food) to pass from the mou ...
without imposing health risks. Once in the
stomach The stomach is a muscular, hollow organ in the upper gastrointestinal tract of Human, humans and many other animals, including several invertebrates. The Ancient Greek name for the stomach is ''gaster'' which is used as ''gastric'' in medical t ...
, the
acids An acid is a molecule or ion capable of either donating a proton (i.e. hydrogen cation, H+), known as a Brønsted–Lowry acid, or forming a covalent bond with an electron pair, known as a Lewis acid. The first category of acids are the ...
and
digestive system The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller compone ...
will remove the phlegm and get rid of the germs in it. In some cultures, swallowing phlegm is considered a social
taboo A taboo is a social group's ban, prohibition or avoidance of something (usually an utterance or behavior) based on the group's sense that it is excessively repulsive, offensive, sacred or allowed only for certain people.''Encyclopædia Britannica ...
, being described as disgusting or unhygienic. One
Igbo Igbo may refer to: * Igbo people, an ethnic group of Nigeria * Igbo language, their language * anything related to Igboland, a cultural region in Nigeria See also * Ibo (disambiguation) * Igbo mythology * Igbo music * Igbo art * * Igbo-Ukwu, a t ...
adage A proverb (from ) or an adage is a simple, traditional saying that expresses a perceived truth based on common sense or experience. Proverbs are often metaphorical and are an example of formulaic speech, formulaic language. A proverbial phrase ...
, for example, uses the swallowing of phlegm as a
metaphor A metaphor is a figure of speech that, for rhetorical effect, directly refers to one thing by mentioning another. It may provide, or obscure, clarity or identify hidden similarities between two different ideas. Metaphors are usually meant to cr ...
for
wrongdoing A wrong or wrength (from Old English – 'crooked') is an act that is illegal or immoral. Legal wrongs are usually quite clearly defined in the law of a state or jurisdiction. They can be divided into civil wrongs and crimes (or ''criminal offe ...
. Also, due to the social image of spitting (the alternative of swallowing) in some communities, females were shown to be more likely to swallow phlegm and less likely to report experiencing it. The alternative to swallowing would be throat-clearing. To do this, the mouth should be closed and air should be
inhaled Inhalation (or inspiration) happens when air or other gases enter the lungs. Inhalation of air Inhalation of air, as part of the cycle of breathing, is a vital process for all human life. The process is autonomic (though there are exceptions ...
hard into the nose. Inhaling forcefully through the nose will pull excess phlegm and nasal mucus down into the throat, where muscles in the throat and
tongue The tongue is a Muscle, muscular organ (anatomy), organ in the mouth of a typical tetrapod. It manipulates food for chewing and swallowing as part of the digestive system, digestive process, and is the primary organ of taste. The tongue's upper s ...
can prepare to eject it. Once this is done, a U-shape should be formed with the tongue, while simultaneously forcing air and
saliva Saliva (commonly referred as spit or drool) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which ...
forward with the muscles at the back of the throat. At this point, the phlegm will be in the mouth and is now ready to be spat out as
sputum Sputum is mucus that is coughed up from the lower airways (the trachea and bronchi). In medicine, sputum samples are usually used for a naked-eye examination, microbiological investigation of respiratory infections, and Cytopathology, cytological ...
.


Colors of phlegm

Phlegm can exist in different colors. The color could provide important clues about a person's health. * Yellow or green: Indicates an infection often by a virus or bacteria. The color is caused by an enzyme produced by the
white blood cells White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign entities. White blood cells are genera ...
combating the infection. * Clear: Indicates
allergies Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
.
Mucous membrane A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It ...
s produce
histamine Histamine is an organic nitrogenous compound involved in local immune responses communication, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Discovered in 19 ...
s and make more phlegm. * Red: Indicates dry air. A
nasal spray Nasal sprays are used to deliver medications Route of administration#Local, locally in the nasal cavities or systemic administration, systemically. They are used locally for conditions such as nasal congestion and allergic rhinitis. In some sit ...
can be used to alleviate symptoms of a dry nose and throat. It can also occur due to blood (such as if the person had or has a
bleeding nose A nosebleed, also known as epistaxis, is an instance of bleeding from the nose. Blood can flow down into the stomach, and cause nausea and vomiting. In more severe cases, blood may come out of both nostrils. Rarely, bleeding may be so significan ...
, or a lung malignancy).


Illnesses related to phlegm

Phlegm may be a carrier of
larva A larva (; : larvae ) is a distinct juvenile form many animals undergo before metamorphosis into their next life stage. Animals with indirect development such as insects, some arachnids, amphibians, or cnidarians typically have a larval phase ...
e of
intestinal parasite An intestinal parasite infection is a condition in which a parasite infects the gastro-intestinal tract of humans and other animals. Such parasites can live anywhere in the body, but most prefer the intestinal wall. Routes of exposure and inf ...
s (see
hookworm Hookworms are Gastrointestinal tract, intestinal, Hematophagy, blood-feeding, parasitic Nematode, roundworms that cause types of infection known as helminthiases. Hookworm infection is found in many parts of the world, and is common in areas with ...
).
Bloody sputum Hemoptysis or haemoptysis is the discharge of blood or blood-stained mucus through the mouth coming from the bronchi, larynx, trachea, or lungs. It does not necessarily involve coughing. In other words, it is the airway bleeding. This can occur ...
can be a symptom of serious disease (such as
tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...
), but can also be a relatively benign symptom of a minor disease (such as
bronchitis Bronchitis is inflammation of the bronchi (large and medium-sized airways) in the lungs that causes coughing. Bronchitis usually begins as an infection in the nose, ears, throat, or sinuses. The infection then makes its way down to the bronchi. ...
). In the latter case, the sputum is normally lightly streaked with blood. Coughing up any significant quantity of blood is always a serious medical condition, and any person who experiences this should seek medical attention. Apophlegmatisms, in pre-modern medicine, were medications chewed in order to draw away phlegm and humours.


History


Phlegm and humourism

Humourism Humorism, the humoral theory, or humoralism, was a system of medicine detailing a supposed makeup and workings of the human body, adopted by Ancient Greek medicine, Ancient Greek and Medicine in ancient Rome, Roman physicians and Greek philosophy ...
is an ancient theory that the human body is filled with four basic substances, called the ''four humours'', which are held in balance when a person is healthy. It is closely related to the ancient theory of the
four elements The classical elements typically refer to earth, water, air, fire, and (later) aether which were proposed to explain the nature and complexity of all matter in terms of simpler substances. Ancient cultures in Greece, Angola, Tibet, India, a ...
and states that all diseases and disabilities result from an excess or deficit in black bile, yellow bile, phlegm, and blood.
Hippocrates Hippocrates of Kos (; ; ), also known as Hippocrates II, was a Greek physician and philosopher of the Classical Greece, classical period who is considered one of the most outstanding figures in the history of medicine. He is traditionally referr ...
, an
ancient Greek Ancient Greek (, ; ) includes the forms of the Greek language used in ancient Greece and the classical antiquity, ancient world from around 1500 BC to 300 BC. It is often roughly divided into the following periods: Mycenaean Greek (), Greek ...
medical doctor, is credited for this theory, about 400 BC. It influenced medical thinking for more than 2,000 years, until finally discredited in the 1800s. Phlegm was thought to be associated with
apathetic Apathy, also referred to as indifference, is a lack of feeling, emotion, interest, or concern about something. It is a state of indifference, or the suppression of emotions such as concern, excitement, motivation, or passion. An apathetic i ...
behaviour; this old belief is preserved in the word "
phlegmatic The four temperament theory is a proto-psychological theory which suggests that there are four fundamental personality types: sanguine, choleric, melancholic, and phlegmatic. Most formulations include the possibility of mixtures among the types ...
". This adjective always refers to behaviour, and is pronounced differently, giving full weight to the "g": not /ˈflɛmatɪk/ but /flɛgˈmatɪk/. To have "phlegm" traditionally meant to have stamina and to be unswayed by emotion. In his 1889 farewell speech at the
University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...
, Sir
William Osler Sir William Osler, 1st Baronet, (; July 12, 1849 – December 29, 1919) was a Canadian physician and one of the "Big Four" founding professors of Johns Hopkins Hospital. Osler created the first Residency (medicine), residency program for speci ...
discussed the imperturbability required of physicians. "'Imperturbability means coolness and presence of mind under all circumstances, calmness amid storm, clearness of judgment in moments of grave peril, immobility, impassiveness, or, to use an old and expressive word, phlegm."'' The phlegm of Humourism is far from the same thing as phlegm as it is defined today. Nobel laureate
Charles Richet Charles Robert Richet (; 25 August 1850 – 4 December 1935) was a French physiologist at the Collège de France and immunology pioneer. In 1913, he won the Nobel Prize in Physiology or Medicine "in recognition of his work on anaphylaxis". Riche ...
MD, when describing humorism's "phlegm or pituitary secretion" in 1910 asked rhetorically, "this strange liquid, which is the cause of tumours, of chlorosis, of rheumatism, and cacochymia - where is it? Who will ever see it? Who has ever seen it? What can we say of this fanciful classification of humours into four groups, of which two are absolutely imaginary?"


References


External links

* * {{Authority control Body fluids Symptoms and signs: Respiratory system