Fenbufen is a
nonsteroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of ...
used to treat pain.
Fenbufen is a member of the
propionic acid derivatives class of drugs.
It was introduced by
American Cyanamid
American Cyanamid Company was a leading American conglomerate which became one of the nation's top 100 manufacturing companies during the 1970s and 1980s, according to the Fortune 500 listings at the time. It started in fertilizer, but added m ...
under the trade name Lederfen in the 1980s. Due to liver toxicity, it was withdrawn from markets in the developed world in 2010.
As of 2015 it was available in Taiwan and Thailand under several brand names.
Preparation
Fenbufen can be synthesized by acylation of
biphenyl with
succinic anhydride
Succinic anhydride, is an organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon- hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms) ...
under
Friedel-Crafts conditions.
[Castillo, Rafael; Suárez-Herrera, Margarita; Aparicio, Mayra; Hernández-Lui, Francisco; Hernández, Alicia (1995). "An Improved Synthesis of Fenbulen". Organic Preparations and Procedures International. 27 (5): 550–552. doi:10.1080/00304949509458497.]
References
Hepatotoxins
Nonsteroidal anti-inflammatory drugs
Withdrawn drugs
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