Fc receptor-like molecules (FCRLs) are a class of proteins that resemble
Fc receptors. They have been characterized in a number of species, including humans and mice. They are preferentially expressed by
B lymphocytes. Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of
antibodies. Their function is unknown.
It has been indicated that FCRLs may be a unique marker for immune cells in the brain called
microglia
Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord. Microglia account for about 7% of cells found within the brain. As the resident macrophage cells, they act as the first and main form of active immune ...
, compared to other CNS cells and peripheral immune cells.
Members
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FCRL1
Fc receptor-like protein 1 is a protein that in humans is encoded by the ''FCRL1'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' ...
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FCRL2
Fc receptor-like protein 2 is a protein that in humans is encoded by the ''FCRL2'' gene.
References
Further reading
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Fc receptors
{{gene-1-stub ...
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FCRL3
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FCRL4
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FCRL5
Fc receptor-like protein 5 is a protein that in humans is encoded by the ''FCRL5'' gene. FCRL5 has also been designated as CD307 (cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification d ...
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FCRL6
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FCRLA
Fc receptor-like A is a protein that in humans is encoded by the ''FCRLA'' gene.
Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily ( IgSF). These receptors mediate phagocytosis o ...
. FCRLA associates with
IgM,
IgG and
IgA.
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FCRLB
See also
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Fc receptor
References
Further reading
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Fc receptors
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