medicine Medicine is the science and Praxis (process), practice of caring for a patient, managing the diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, and Health promotion ...

, the Faget sign—sometimes called sphygmothermic dissociation—is the unusual pairing of

fever Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...

with

bradycardia Bradycardia (also sinus bradycardia) is a slow resting heart rate, commonly under 60 beats per minute (BPM) as determined by an electrocardiogram. It is considered to be a normal heart rate during sleep, in young and healthy or elderly adults, ...

(slow

pulse In medicine, a pulse represents the tactile arterial palpation of the cardiac cycle (heartbeat) by trained fingertips. The pulse may be palpated in any place that allows an artery to be compressed near the surface of the body, such as at the ...

). (Fever is usually accompanied by

tachycardia Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate. In general, a resting heart rate over 100 beats per minute is accepted as tachycardia in adults. Heart rates above the resting rate may be normal ( ...

(rapid pulse), an association known by the

eponym An eponym is a person, a place, or a thing after whom or which someone or something is, or is believed to be, named. The adjectives which are derived from the word eponym include ''eponymous'' and ''eponymic''. Usage of the word The term ''epon ...

Liebermeister's rule Liebermeister's rule concerns the increment ratio between an adult individual's cardiac frequency and temperature when in fever. Each Celsius grade of body temperature increment corresponds to an 8 ''beats per minute'' increase in cardiac frequency, ...

".) The Faget sign is named after Louisiana physician

Jean Charles Faget Jean Charles Faget was a medical doctor born on June 26, 1818 in New Orleans. He is best known for the Faget sign—a medical sign that is the unusual combination of fever and bradycardia. The sign is an important diagnostic symptom of yello ...

, who studied

yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In ...

in Louisiana. Faget sign is often seen in: *

Yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In ...

Typhoid fever Typhoid fever, also known as typhoid, is a disease caused by '' Salmonella'' serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over severa ...

Brain abscess Brain abscess (or cerebral abscess) is an abscess caused by inflammation and collection of infected material, coming from local (ear infection, dental abscess, infection of paranasal sinuses, infection of the mastoid air cells of the temporal b ...

Tularaemia Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium '' Francisella tularensis''. Symptoms may include fever, skin ulcers, and enlarged lymph nodes. Occasionally, a form that results in pneumonia or a thro ...

Brucellosis Brucellosis is a highly contagious zoonosis caused by ingestion of unpasteurized milk or undercooked meat from infected animals, or close contact with their secretions. It is also known as undulant fever, Malta fever, and Mediterranean fever. T ...

Colorado tick fever Colorado tick fever (CTF) is a viral infection (Coltivirus) transmitted from the bite of an infected Rocky Mountain wood tick (''Dermacentor andersoni''). It should not be confused with the bacterial tick-borne infection, Rocky Mountain spotted fev ...

*Some

pneumonia Pneumonia is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli. Symptoms typically include some combination of productive or dry cough, chest pain, fever, and difficulty breathing. The severi ...

s - ''

Legionella ''Legionella'' is a genus of pathogenic gram-negative bacteria that includes the species '' L. pneumophila'', causing legionellosis (all illnesses caused by ''Legionella'') including a pneumonia-type illness called Legionnaires' disease and a mil ...

'' pneumonia and ''

Mycoplasma ''Mycoplasma'' is a genus of bacteria that, like the other members of the class '' Mollicutes'', lack a cell wall around their cell membranes. Peptidoglycan ( murein) is absent. This characteristic makes them naturally resistant to antibiotic ...

'' pneumonia *Drug fever (e.g. beta-blockers,Neuroimmunomodulation. 1999 Jul-Aug;6(4):305-17. Beta-adrenergic receptor subtype effects on stress fever and thermoregulation. Mayfield KP, Soszynski D, Kozak W, Kozak A, Rudolph K, Kluger MJ. known as the Beta-Faget sign) Of note, the Faget sign in bacterial infections is consistently associated with bacteria that have an intracellular life cycle.

References

Medical signs {{med-sign-stub