Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''FMNL3''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

The protein encoded by this gene contains a

formin Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins re ...

homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different

isoform A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic differences. While many perform the same or similar biological roles, some isoforms have uniqu ...

s have been described. The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif. FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.

Function

See also

References

Further reading